EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA. Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening | diphosphate + RNAn+1 | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? | |
2.7.7.48 | nucleoside triphosphate + RNAn | key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA. Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening | Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
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EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
2.7.7.48 | RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.48 | drug target | target for antiviral drugs | Severe acute respiratory syndrome coronavirus 2 |
2.7.7.48 | physiological function | key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA | Severe acute respiratory syndrome coronavirus 2 |