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Literature summary extracted from

  • Li, M.; Min, W.; Wang, J.; Wang, L.; Li, Y.; Zhou, N.; Yang, Z.; Qian, Q.
    Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate (2020), Exp. Therap. Med., 19, 2861-2870 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.36 the mevalonate kinase (MVK) gene has 10 coding exons and one non-coding exon at chromosome 12q24, the MVK protein is encoded by two transcripts of MVK. Recombinant expression of the enzyme in HaCat human keratinocytes using viral vectors, quantitative reverse transcription-PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.36 additional information recombinant expression of the enzyme in HaCat human keratinocytes causes interference with the expression of other genes. The mRNA and protein expression levels of keratin 1 and involucrin are significantly decreased following interference of MVK expression, and the decrease is markedly attenuated by farnesyl diphosphate (FPP). Furthermore, the apoptotic rate is markedly increased following MVK interference, and the increase is significantly attenuated by geranylxadgeranyl diphosphate (GGPP). Overexpression of MVK significantly decreased the apoptotic rate of HaCat cells. The prenylation levels after MVK interference is notably decreased, which is markedly attenuated by GGPP. The overexpression of MVK significantly increased the prenylation levels of HaCat cells. FPP or GGPP reverse MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.36 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate Homo sapiens
-
 ADP + (R)-5-phosphomevalonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Homo sapiens Q03426
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.36 HaCaT cell
-
 Homo sapiens
-
2.7.1.36 keratinocyte
-
 Homo sapiens
-
2.7.1.36 additional information MVK is ubiquitously expressed Homo sapiens
-
2.7.1.36 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate
-
 Homo sapiens ADP + (R)-5-phosphomevalonate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.36 MVK
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.36 metabolism MVK functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Short-chain isoprenoids farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are the intermediate products of the mevalonate pathway, these attach to small G proteins covalently, and serve as molecular switches in many biochemical pathways Homo sapiens
2.7.1.36 physiological function MVK catalyzes the phosphorylation of mevalonic acid into 5-phosphomevalonate, and functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Analysis of the role of MVK in differentiation, apoptosis and prenylation of keratinocytes, and in the expression of keratin 1 and involucrin, protein prenylation and the processing of small G proteins, overview Homo sapiens