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Literature summary extracted from

  • Torretta, S.; Colombo, G.; Travelli, C.; Boumya, S.; Lim, D.; Genazzani, A.A.; Grolla, A.A.
    The cytokine nicotinamide phosphoribosyltransferase (eNAMPT; PBEF; visfatin) acts as a natural antagonist of C-C chemokine receptor type 5 (CCR5) (2020), Cells, 9, 496 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.12 expressed in Escherichia coli BL21(DE3) cells Mus musculus
2.4.2.12 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.12 extracellular
-
 Mus musculus
-
-
2.4.2.12 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-
2.4.2.12 Mus musculus Q99KQ4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.12 Ni-NTA resin column chromatography Mus musculus
2.4.2.12 Ni-NTA resin column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 B-16 cell
-
 Mus musculus
-
2.4.2.12 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 additional information the enzyme binds to the C-C chemokine receptor type 5 and acts as a natural antagonist of this receptor Mus musculus ?
-
-
2.4.2.12 additional information the enzyme binds to the C-C chemokine receptor type 5 and acts as a natural antagonist of this receptor Homo sapiens ?
-
-
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 eNAMPT
-
 Mus musculus
2.4.2.12 eNAMPT
-
 Homo sapiens
2.4.2.12 extracellular nicotinamide phosphoribosyltrasferase
-
 Mus musculus
2.4.2.12 extracellular nicotinamide phosphoribosyltrasferase
-
 Homo sapiens
2.4.2.12 PBEF
-
 Mus musculus
2.4.2.12 PBEF
-
 Homo sapiens
2.4.2.12 Visfatin
-
 Mus musculus
2.4.2.12 Visfatin
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.12 physiological function the enzyme inhibits Rantes-induced Ca2+-rises and Rantes-induced migration in melanoma cells Mus musculus
2.4.2.12 physiological function the enzyme inhibits Rantes-induced Ca2+-rises and Rantes-induced migration in melanoma cells Homo sapiens