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Literature summary extracted from

  • Sharma, S.; Mathre, S.; Ramya, V.; Shinde, D.; Raghu, P.
    Phosphatidylinositol 5 phosphate 4-kinase regulates plasma-membrane PIP3 turnover and insulin signaling (2019), Cell Rep., 27, 1979-1990 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.149 expressed in a enzyme-deficient mutant of Drosophila melanogaster Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.149 plasma membrane
-
 Drosophila melanogaster 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.149 Mg2+ 20 mM used in assay conditions Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Drosophila melanogaster
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.149 fat body
-
 Drosophila melanogaster
-
2.7.1.149 salivary gland
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 phosphatidylinositol 5 phosphate 4-kinase
-
 Drosophila melanogaster
2.7.1.149 PIP4K
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.1.149 malfunction enzyme-deficient animals show enhanced insulin signaling-dependent phenotypes and are resistant to the metabolic consequences of a high-sugar diet Drosophila melanogaster
2.7.1.149 metabolism the enzyme regulates plasma-membrane phosphatidylinositol 3,4,5-trisphosphate turnover and insulin signalling. The enzyme is required to limit phosphatidylinositol 3,4,5-trisphosphate levels during insulin receptor activation Drosophila melanogaster