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Literature summary extracted from

  • Zhang, L.Q.; Van Haandel, L.; Xiong, M.; Huang, P.; Heruth, D.P.; Bi, C.; Gaedigk, R.; Jiang, X.; Li, D.Y.; Wyckoff, G.; Grigoryev, D.N.; Gao, L.; Li, L.; Wu, M.; Leeder, J.S.; Ye, S.Q.
    Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase (2017), Cell Death Dis., 8, e2705 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Mus musculus Q99KQ4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.12 ? x * 56000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.2.12 malfunction homozygous enzyme knockout results in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24% body weight loss Mus musculus
2.4.2.12 physiological function the enzyme is an essential gene for adult mouse survival. The enzyme is involved in key basic cellular functions such as transcription, translation, cell signaling, and fundamental metabolism Mus musculus