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Literature summary extracted from

  • Wu, C.; Lan, L.; Li, Y.; Nie, Z.; Zeng, R.
    The relationship between latex metabolism gene expression with rubber yield and related traits in Hevea brasiliensis (2018), BMC Genomics, 19, 897 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Hevea brasiliensis the enzyme is implicated in latex metabolism (R)-mevalonate + CoA + 2 NADP+
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Hevea brasiliensis the enzyme is implicated in latex metabolism (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.5.1.20 cis-farnesyl diphosphate + isopentenyl diphosphate Hevea brasiliensis the enzyme is involved in the production of natural rubber. It catalyzes the sequential cis-1,4-condensation of isopentenyl diphosphate with cis-farnesyl diphosphate and its growing chains diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit
-
 ?
2.5.1.20 polycis-polyprenyl diphosphate + isopentenyl diphosphate Hevea brasiliensis the enzyme is involved in the production of natural rubber. It catalyzes the sequential cis-1,4-condensation of isopentenyl diphosphate with cis-farnesyl diphosphate and its growing chains diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit
-
 ?
4.1.1.33 ATP + (R)-5-diphosphomevalonate Hevea brasiliensis the enzyme is implicated in latex metabolism ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
4.2.1.9 2,3-dihydroxy-3-methylbutanoate Hevea brasiliensis the enzyme is implicated in latex metabolism 3-methyl-2-oxobutanoate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Hevea brasiliensis Q547W6
-
-
2.3.3.10 Hevea brasiliensis Q944F8
-
-
2.5.1.20 Hevea brasiliensis Q8W3U4
-
-
4.1.1.33 Hevea brasiliensis A9ZN03
-
-
4.2.1.9 Hevea brasiliensis A0A481UJA7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 leaf strongly expressed in leaves Hevea brasiliensis
-
2.3.3.10 bark strongly expressed in latex and bark Hevea brasiliensis
-
2.3.3.10 latex strongly expressed in latex and bark Hevea brasiliensis
-
2.5.1.20 bark strongly expressed in latex and bark Hevea brasiliensis
-
2.5.1.20 latex strongly expressed in latex and bark Hevea brasiliensis
-
4.1.1.33 leaf strongly expressed in leaves Hevea brasiliensis
-
4.2.1.9 leaf strongly expressed in leaves Hevea brasiliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Hevea brasiliensis (R)-mevalonate + CoA + 2 NADP+
-
 ?
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ the enzyme is implicated in latex metabolism Hevea brasiliensis (R)-mevalonate + CoA + 2 NADP+
-
 ?
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA the enzyme is implicated in latex metabolism Hevea brasiliensis (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.5.1.20 cis-farnesyl diphosphate + isopentenyl diphosphate the enzyme is involved in the production of natural rubber. It catalyzes the sequential cis-1,4-condensation of isopentenyl diphosphate with cis-farnesyl diphosphate and its growing chains Hevea brasiliensis diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit
-
 ?
2.5.1.20 polycis-polyprenyl diphosphate + isopentenyl diphosphate
-
 Hevea brasiliensis diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit
-
 ?
2.5.1.20 polycis-polyprenyl diphosphate + isopentenyl diphosphate the enzyme is involved in the production of natural rubber. It catalyzes the sequential cis-1,4-condensation of isopentenyl diphosphate with cis-farnesyl diphosphate and its growing chains Hevea brasiliensis diphosphate + a polycis-polyprenyl diphosphate longer by one C5 unit
-
 ?
4.1.1.33 ATP + (R)-5-diphosphomevalonate
-
 Hevea brasiliensis ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme is implicated in latex metabolism Hevea brasiliensis ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
4.2.1.9 2,3-dihydroxy-3-methylbutanoate
-
 Hevea brasiliensis 3-methyl-2-oxobutanoate + H2O
-
 ?
4.2.1.9 2,3-dihydroxy-3-methylbutanoate the enzyme is implicated in latex metabolism Hevea brasiliensis 3-methyl-2-oxobutanoate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
 Hevea brasiliensis
1.1.1.34 HMGR1
-
 Hevea brasiliensis
2.3.3.10 HMG-CoA synthase
-
 Hevea brasiliensis
2.3.3.10 HMGS
-
 Hevea brasiliensis
2.5.1.20 cis-prenyltransferase
-
 Hevea brasiliensis
2.5.1.20 CPT
-
 Hevea brasiliensis
4.1.1.33 PMD
-
 Hevea brasiliensis
4.2.1.9 DHAD
-
 Hevea brasiliensis

Expression

EC Number Organism Comment Expression
1.1.1.34 Hevea brasiliensis rubber yields and/or yield characteristics are significantly positively correlated with enzyme expression levels up
2.3.3.10 Hevea brasiliensis rubber yields and/or yield characteristics are significantly negatively correlated with enzyme expression levels up
2.5.1.20 Hevea brasiliensis rubber yields and/or yield characteristics are significantly positively correlated with enzyme expression levels. The up-regulation of the gene might be related to the latex production of rubber trees under the stress of bark tapping and latex metabolism. Both bark tapping and ethephon and methyl jasmonate stimulation could significantly increase the transcript levels, which shows the greatest expression levels during the last stage of incipient tapping after tree opening up
4.2.1.9 Hevea brasiliensis rubber yields and/or yield characteristics are significantly positively correlated with expression levels up

General Information

EC Number General Information Comment Organism
1.1.1.34 metabolism the enzyme is implicated in latex metabolism Hevea brasiliensis
2.3.3.10 metabolism the enzyme is implicated in latex metabolism Hevea brasiliensis
2.5.1.20 metabolism the enzyme is implicated in latex metabolism Hevea brasiliensis
4.1.1.33 metabolism the enzyme is implicated in latex metabolism. Rubber yields and/or yield characteristics are not significantly correlated with enzyme expression levels Hevea brasiliensis
4.2.1.9 metabolism the enzyme is implicated in latex metabolism Hevea brasiliensis