Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Frohnhoefer, H.G.; Geiger-Rudolph, S.; Pattky, M.; Meixner, M.; Huhn, C.; Maischein, H.M.; Geisler, R.; Gehring, I.; Maderspacher, F.; Nuesslein-Volhard, C.; Irion, U.
    Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish (2016), Biol. Open, 5, 736-744 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.16 additional information idefix(t26743), a mutation with a premature stop codon in the zebrafish gene encoding the enzyme spermidine synthase, leads to a severe reduction in spermidine levels Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine Danio rerio
-
 S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Danio rerio F1R3G8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl 3-(methylsulfanyl)propylamine + putrescine
-
 Danio rerio S-methyl-5'-thioadenosine + spermidine
-
 ?

General Information

EC Number General Information Comment Organism
2.5.1.16 malfunction maternal loss of spermidine synthase leads to lethality and defects in pancreas development Danio rerio
2.5.1.16 physiological function in zebrafish spermidine, but not spermine, is essential for early development, organogenesis and colour pattern formation Danio rerio