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Literature summary extracted from

  • Ahmad, F.; Tomar, D.; Aryal A C, S.; Elmoselhi, A.B.; Thomas, M.; Elrod, J.W.; Tilley, D.G.; Force, T.
    Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling (2020), Biochim. Biophys. Acta, 1866, 165609 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.22 gene NMRK2 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.22 additional information generation of NRK2 knockout (KO) mice Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.22 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide Mus musculus
-
 ADP + beta-nicotinamide D-ribonucleotide
-
 ?
2.7.1.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide Mus musculus C57BL/6N
-
 ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.22 Homo sapiens Q9NPI5
-
-
2.7.1.22 Mus musculus Q9D7C9
-
-
2.7.1.22 Mus musculus C57BL/6N Q9D7C9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.22 cardiac muscle
-
 Mus musculus
-
2.7.1.22 fibroblast
-
 Mus musculus
-
2.7.1.22 heart predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue Homo sapiens
-
2.7.1.22 heart predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue Mus musculus
-
2.7.1.22 myofibroblast
-
 Mus musculus
-
2.7.1.22 skeletal muscle
-
 Mus musculus
-
2.7.1.22 skeletal muscle predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue Homo sapiens
-
2.7.1.22 skeletal muscle predominantly expresses in skeletal muscle with a trace amount expressed in healthy cardiac tissue Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
-
 Mus musculus ADP + beta-nicotinamide D-ribonucleotide
-
 ?
2.7.1.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
-
 Mus musculus C57BL/6N ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.22 muscle-specific beta1 integrin binding protein
-
 Mus musculus
2.7.1.22 nicotinamide riboside kinase-2
-
 Homo sapiens
2.7.1.22 nicotinamide riboside kinase-2
-
 Mus musculus
2.7.1.22 NMRK2
-
 Mus musculus
2.7.1.22 NRK-2
-
 Homo sapiens
2.7.1.22 NRK-2
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.22 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.22 Homo sapiens NRK-2 expression dramatically increases in ischemic heart up
2.7.1.22 Mus musculus NRK-2 expression dramatically increases in ischemic heart up

General Information

EC Number General Information Comment Organism
2.7.1.22 malfunction loss of NRK-2 enhances p38alpha activation following ischemic injury Mus musculus
2.7.1.22 malfunction NRK-2 plays a critical role in heart failure progression following ischemic injury. NRK-2 deficiency promotes post-MI scar expansion, rapid LV chamber dilatation, cardiac dysfunction and fibrosis possibly due to increased p38slphs activation Homo sapiens
2.7.1.22 malfunction loss of NRK-2 enhanced p38alpha activation following ischemic injury. The gain of NRK-2 function suppresses the p38alpha as well as fibroblast activation (alpha-SMA expression) upon TGF-beta stimulation, and limits cardiomyocytes death upon hypoxia/re-oxygenation. Role of NRK-2 in ischemia-induced cardiac remodeling and dysfunction, overview Mus musculus
2.7.1.22 physiological function NRK-2 plays a critical role in heart failure progression following ischemic injury. NRK-2 deficiency promotes post-MI scar expansion, rapid LV chamber dilatation, cardiac dysfunction and fibrosis possibly due to increased p38slphs activation Homo sapiens
2.7.1.22 physiological function nicotinamide riboside kinase-2 (NRK-2) is a muscle-specific beta1 integrin binding protein, that is predominantly expressed in skeletal muscle with a trace amount expressed in healthy cardiac tissue. Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling, role of NRK-2 in ischemia-induced cardiac remodeling and dysfunction, overview. NRK-2 plays a role in the NAD+ salvage pathway, but the role of NRK-2 in NAD+ synthesis is dispensable. NRK-2 may regulate cardiac pathophysiology of heart failure. NRK-2 mitigates TGF-beta-induced myofibroblast transformation Mus musculus