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Literature summary extracted from

  • Droubi, A.; Bulley, S.; Clarke, J.; Irvine, R.
    Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases alpha and beta are dynamic and independently regulated during starvation-induced stress (2016), Biochem. J., 473, 2155-2163 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.149 cytoplasm isoform PI5P4Kalpha is predominantly (possible entirely) cytoplasmic when isoform PI5P4Kbeta is stably deleted from cells. In contrast, when PI5P4Kbeta is inducibly removed within 1 h PI5P4Kalpha retains its wild-type distribution of approximately 50:50 between cytoplasm and nucleus Gallus gallus 5737
-
2.7.1.149 nucleus isoform PI5P4Kalpha is chromatin-associated. In the exponential phase of growth PI5P4Kbeta is primarily cytoplasmic but translocates to the nucleus upon growth into the stationary phase or upon serum starvation Gallus gallus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.149 95000
-
 isoform PI5P4Kgamma, gel filtration Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Gallus gallus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.149 DT-40 cell
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Gallus gallus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.149 homodimer 2 * 47000, isoform PI5P4Kgamma, SDS-PAGE Gallus gallus
2.7.1.149 homodimer 2 * 70000, enhanced monomeric green fluorescent protein-tagged isoform PI5P4Kalpha, SDS-PAGE Gallus gallus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 phosphatidylinositol 5-phosphate 4-kinase
-
 Gallus gallus
2.7.1.149 PI5P4Kalpha isoform Gallus gallus
2.7.1.149 PI5P4Kbeta isoform Gallus gallus
2.7.1.149 PI5P4Kgamma isoform Gallus gallus