Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ohren, J.; Parungao, G.G.; Viola, R.E.
    Structure of a critical metabolic enzyme S-adenosylmethionine synthetase from Cryptosporidium parvum (2019), Acta Crystallogr. Sect. F, 75, 290-298 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.5.1.6 drug development the enzyme form has a less extensive subunit interface than some previously determined structures, and contains some key structural differences from the human enzyme in an allosteric site, presenting an opportunity for the design of selective inhibitors against the S-adenosylmethionine synthetase from this organism Cryptosporidium parvum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.6 expression in Escherichia coli Cryptosporidium parvum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.6 hanging-drop vapor diffusion method at 20°C Cryptosporidium parvum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O Cryptosporidium parvum
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O Cryptosporidium parvum Iowa II
-
 phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Cryptosporidium parvum Q5CYE4
-
-
2.5.1.6 Cryptosporidium parvum Iowa II Q5CYE4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.6
-
 Cryptosporidium parvum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
 Cryptosporidium parvum phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?
2.5.1.6 ATP + L-methionine + H2O
-
 Cryptosporidium parvum Iowa II phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.6 AdoMet synthetase
-
 Cryptosporidium parvum
2.5.1.6 MetK
-
 Cryptosporidium parvum
2.5.1.6 S-adenosylmethionine synthetase
-
 Cryptosporidium parvum

General Information

EC Number General Information Comment Organism
2.5.1.6 metabolism S-adenosyl-L-methionine (AdoMet) is the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism Cryptosporidium parvum