Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ivashkin, E.; Melnikova, V.; Kurtova, A.; Brun, N.R.; Obukhova, A.; Khabarova, M.Y.; Yakusheff, A.; Adameyko, I.; Gribble, K.E.; Voronezhskaya, E.E.
    Transglutaminase activity determines nuclear localization of serotonin immunoreactivity in the early embryos of invertebrates and vertebrates (2019), ACS Chem. Neurosci., 10, 3888-3899 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 cystamine
-
 Mesocentrotus nudus
2.3.2.13 cystamine
-
 Paracentrotus lividus
2.3.2.13 cystamine
-
 Scaphechinus mirabilis
2.3.2.13 Monodansylcadaverine
-
 Mesocentrotus nudus
2.3.2.13 Monodansylcadaverine
-
 Paracentrotus lividus
2.3.2.13 Monodansylcadaverine
-
 Scaphechinus mirabilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 additional information fluorescence immunohistochemical localization, overview. Brightest 5-HT-ir spots appear at the apical region of all ectodermal cells, and are not associated with nuclei of any cells Mesocentrotus nudus
-
-
2.3.2.13 additional information fluorescence immunohistochemical localization, overview. Brightest 5-HT-ir spots appear at the apical region of all ectodermal cells, and are not associated with nuclei of any cells Scaphechinus mirabilis
-
-
2.3.2.13 additional information fluorescence immunohistochemical localization, overview. Most anti-5-HT staining is associated with nuclear material Paracentrotus lividus
-
-
2.3.2.13 nucleus
-
 Paracentrotus lividus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 protein glutamine + 5-hydroxytryptamine Mesocentrotus nudus
-
 protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine Paracentrotus lividus
-
 protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine Scaphechinus mirabilis
-
 protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine Mesocentrotus nudus
-
 protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine Paracentrotus lividus
-
 protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine Scaphechinus mirabilis
-
 protein N5-alkylglutamine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Mesocentrotus nudus
-
-
-
2.3.2.13 Paracentrotus lividus Q8T316
-
-
2.3.2.13 Scaphechinus mirabilis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 blastula
-
 Mesocentrotus nudus
-
2.3.2.13 blastula
-
 Paracentrotus lividus
-
2.3.2.13 blastula
-
 Scaphechinus mirabilis
-
2.3.2.13 ectoderm
-
 Mesocentrotus nudus
-
2.3.2.13 ectoderm
-
 Scaphechinus mirabilis
-
2.3.2.13 embryo
-
 Mesocentrotus nudus
-
2.3.2.13 embryo
-
 Paracentrotus lividus
-
2.3.2.13 embryo
-
 Scaphechinus mirabilis
-
2.3.2.13 additional information enzyme expression analysis and fluorescence histochemical localization, overview Mesocentrotus nudus
-
2.3.2.13 additional information enzyme expression analysis and fluorescence histochemical localization, overview Paracentrotus lividus
-
2.3.2.13 additional information enzyme expression analysis and fluorescence histochemical localization, overview Scaphechinus mirabilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 protein glutamine + 5-hydroxytryptamine
-
 Mesocentrotus nudus protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine
-
 Paracentrotus lividus protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine
-
 Scaphechinus mirabilis protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine immunohistochemic detection of 5-HT Mesocentrotus nudus protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine immunohistochemic detection of 5-HT Paracentrotus lividus protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + 5-hydroxytryptamine immunohistochemic detection of 5-HT Scaphechinus mirabilis protein N5-(5-hydroxy)tryptaminyl-glutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine
-
 Mesocentrotus nudus protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine
-
 Paracentrotus lividus protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein glutamine + alkylamine
-
 Scaphechinus mirabilis protein N5-alkylglutamine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.13 transglutaminase
-
 Mesocentrotus nudus
2.3.2.13 transglutaminase
-
 Paracentrotus lividus
2.3.2.13 transglutaminase
-
 Scaphechinus mirabilis
2.3.2.13 transglutaminase-like protein UniProt Paracentrotus lividus

General Information

EC Number General Information Comment Organism
2.3.2.13 physiological function serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation Mesocentrotus nudus
2.3.2.13 physiological function serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation Paracentrotus lividus
2.3.2.13 physiological function serotonin (5-hydroxytryptamine, 5-HT) is a key player in many physiological processes in both the adult organism and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent binding of 5-HT to the target proteins catalyzed by transglutaminases (serotonylation). In some cases, protein serotonylation (or generally monoaminylation) may lead to the formation of an active or inactive molecule that remains stable until its proteolytic degradation Scaphechinus mirabilis