EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.2.2.9 | 5'-(2-ethylhex-1-yl)thio-DADMe-immucillin A | - |
Mycobacterium tuberculosis | |
3.2.2.9 | 5'-(4-chlorophenyl)thio-DADMe-immucillin A | - |
Mycobacterium tuberculosis | |
3.2.2.9 | 5'-(4-hydroxybutyl)thio-DADMe-immucillin A | - |
Mycobacterium tuberculosis | |
3.2.2.9 | 5'-butylthio-DADMe-immucillin A | - |
Mycobacterium tuberculosis | |
3.2.2.9 | 5'-hexylthio-DADMe-immucillin A | most potent inhibitor | Mycobacterium tuberculosis | |
3.2.2.9 | 5'-methylthio-DADMe-immucillin A | - |
Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.9 | 0.0037 | - |
5'-methylthioadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.0109 | - |
5'-deoxyadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.0631 | - |
S-adenosyl-L-homocysteine | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.2.9 | Mycobacterium tuberculosis | P9WJM3 | - |
- |
3.2.2.9 | Mycobacterium tuberculosis H37Rv | P9WJM3 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.2.9 | 5'-deoxyadenosine + H2O | preferred substrate | Mycobacterium tuberculosis | 5-deoxy-D-ribose + adenine | - |
ir | |
3.2.2.9 | 5'-deoxyadenosine + H2O | preferred substrate | Mycobacterium tuberculosis H37Rv | 5-deoxy-D-ribose + adenine | - |
ir | |
3.2.2.9 | 5'-methylthioadenosine + H2O | - |
Mycobacterium tuberculosis | 5-methylthio-D-ribose + adenine | - |
ir | |
3.2.2.9 | 5'-methylthioadenosine + H2O | - |
Mycobacterium tuberculosis H37Rv | 5-methylthio-D-ribose + adenine | - |
ir | |
3.2.2.9 | S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
ir | |
3.2.2.9 | S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
ir |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.2.2.9 | homodimer | 2 * 30900, SDS-PAGE | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.2.9 | 5'-dAdo nucleosidase | - |
Mycobacterium tuberculosis |
3.2.2.9 | 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase | - |
Mycobacterium tuberculosis |
3.2.2.9 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | - |
Mycobacterium tuberculosis |
3.2.2.9 | MTAN | - |
Mycobacterium tuberculosis |
3.2.2.9 | Rv0091 | - |
Mycobacterium tuberculosis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.9 | 0.004 | - |
S-adenosyl-L-homocysteine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.023 | - |
5'-methylthioadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.47 | - |
5'-deoxyadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.9 | 0.000000087 | - |
5'-hexylthio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.000000099 | - |
5'-(2-ethylhex-1-yl)thio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.000000258 | - |
5'-(4-chlorophenyl)thio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.000000606 | - |
5'-(4-hydroxybutyl)thio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.0000013 | - |
5'-butylthio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 0.0000015 | - |
5'-methylthio-DADMe-immucillin A | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.2.2.9 | 0.06 | - |
S-adenosyl-L-homocysteine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 6.3 | - |
5'-methylthioadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
3.2.2.9 | 43.4 | - |
5'-deoxyadenosine | pH and temperature not specified in the publication | Mycobacterium tuberculosis |