Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lamparter, C.; Winn, L.
    Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells (2016), Toxicol. Appl. Pharmacol., 306, 69-78 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 C646
-
 Mus musculus
2.3.1.48 Valproic acid
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine Mus musculus
-
 CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Mus musculus B2RWS6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 P-19 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine
-
 Mus musculus CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Cbp
-
 Mus musculus
2.3.1.48 HAT
-
 Mus musculus
2.3.1.48 p300
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.48 Mus musculus the expression of nuclear and total cellular enzyme proteins is decreased following 5 mM valproic acid exposure for 6 h down

General Information

EC Number General Information Comment Organism
2.3.1.48 malfunction enzyme deficiency is associated with congenital malformations and embryolethality. Enzyme inhibition induces oxidative stress Mus musculus