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Literature summary extracted from

  • Kim, J.H.; Jung, D.Y.; Nagappan, A.; Jung, M.H.
    Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARgamma2 (2018), Sci. Rep., 8, 13734 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Mus musculus overall reaction [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Homo sapiens overall reaction [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.66 Homo sapiens
-
-
-
1.14.11.66 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.66 Hep-G2 cell
-
 Homo sapiens
-
1.14.11.66 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Mus musculus [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Homo sapiens [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.66 JMJD2B
-
 Mus musculus
1.14.11.66 JMJD2B
-
 Homo sapiens
1.14.11.66 KDM4B
-
 Mus musculus
1.14.11.66 KDM4B
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.11.66 Homo sapiens enzyme expression is markedly increased in Hep-G2 cells treated with palmitate and oleate or liver X receptor agonist T09013178 up
1.14.11.66 Mus musculus enzyme expression is markedly increased in the liver of high-fat diet-induced obese mice up

General Information

EC Number General Information Comment Organism
1.14.11.66 physiological function enzyme expression in mice results in hepatic steatosis when fed a high-fat diet, which is accompanied with increased expression of hepatic peroxisome proliferator-activated receptor gamma2 and its steatosis target genes Mus musculus
1.14.11.66 physiological function enzyme overexpression in HepG2 cells stimulates the expression of peroxisome proliferator-activated receptor gamma2 (PPARgamma2) and its steatosis target genes associated with fatty acid uptake and lipid droplet formation, resulting in increased intracellular triglyceride accumulation. Enzyme-dependent upregulation of PPARgamma2 is associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2 Homo sapiens