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Literature summary extracted from

  • Eich, M.L.; Chandrashekar, D.S.; Rodriguez Pen A, M.D.C.; Robinson, A.D.; Siddiqui, J.; Daignault-Newton, S.; Chakravarthi, B.V.S.K.; Kunju, L.P.; Netto, G.J.; Varambally, S.
    Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer (2019), Prostate, 79, 1629-1639 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.68 medicine GLYATL1 is overexpressed in primary prostate cancer compared with metastatic prostate cancer and benign prostatic tissue. Low-grade cancers have higher GLYATL1 expression compared to high-grade prostate tumors. GLYATL1 is upregulated upon androgen treatment in LNCaP prostate cancer cells which harbor ETV1 gene rearrangement. ETV1 knockdown in LNCaP cells shows downregulation of GLYATL1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.13 acyl-CoA + glycine Homo sapiens
-
 CoA + N-acylglycine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.13 Homo sapiens
-
-
-
2.3.1.68 Homo sapiens Q969I3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.13 CWR22-Rv1 cell
-
 Homo sapiens
-
2.3.1.13 DU-145 cell
-
 Homo sapiens
-
2.3.1.13 LNCaP cell
-
 Homo sapiens
-
2.3.1.13 LNCAP-C4-2B cell
-
 Homo sapiens
-
2.3.1.13 PC-3 cell
-
 Homo sapiens
-
2.3.1.13 prostate gland cancer cell
-
 Homo sapiens
-
2.3.1.13 RWPE-1 cell
-
 Homo sapiens
-
2.3.1.13 VCaP cell
-
 Homo sapiens
-
2.3.1.68 LNCaP cell
-
 Homo sapiens
-
2.3.1.68 prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.13 acyl-CoA + glycine
-
 Homo sapiens CoA + N-acylglycine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.13 GLYATL1
-
 Homo sapiens
2.3.1.13 glycine-N-acyltransferase like 1
-
 Homo sapiens
2.3.1.68 GLYATL!
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.13 Homo sapiens the enzyme is overexpressed in primary prostate cancer compared with metastatic prostate cancer and benign prostatic tissue. Low-grade cancers have higher enzyme expression compared to high-grade prostate tumors up