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Literature summary extracted from

  • Gasiorowski, E.; Auger, R.; Tian, X.; Hicham, S.; Ecobichon, C.; Roure, S.; Douglass, M.V.; Trent, M.S.; Mengin-Lecreulx, D.; Touze, T.; Boneca, I.G.
    HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach (2019), PLoS Pathog., 15, e1007972 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.27 expressed in Escherichia coli C43(DE3) cells Helicobacter pylori

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.27 membrane
-
 Helicobacter pylori 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.27 Helicobacter pylori
-
-
-
3.6.1.27 Helicobacter pylori N6
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.27 Ni-NTA agarose bead chromatography Helicobacter pylori

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.27 0.958
-
 with phosphatidylglycerol phosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
3.6.1.27 6.019
-
 with isopentenyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
3.6.1.27 6.039
-
 with undecaprenyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
3.6.1.27 24.084
-
 with diacylglycerol diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
3.6.1.27 160.406
-
 with farnesyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.27 diacylglycerol diphosphate + H2O
-
 Helicobacter pylori diacylglycerol phosphate + phosphate
-
 ?
3.6.1.27 diacylglycerol diphosphate + H2O
-
 Helicobacter pylori N6 diacylglycerol phosphate + phosphate
-
 ?
3.6.1.27 farnesyl diphosphate + H2O
-
 Helicobacter pylori farnesyl phosphate + phosphate
-
 ?
3.6.1.27 farnesyl diphosphate + H2O
-
 Helicobacter pylori N6 farnesyl phosphate + phosphate
-
 ?
3.6.1.27 isopentenyl diphosphate + H2O
-
 Helicobacter pylori isopentenyl phosphate + phosphate
-
 ?
3.6.1.27 isopentenyl diphosphate + H2O
-
 Helicobacter pylori N6 isopentenyl phosphate + phosphate
-
 ?
3.6.1.27 additional information no activity with phosphatidic acid Helicobacter pylori ?
-
-
3.6.1.27 additional information no activity with phosphatidic acid Helicobacter pylori N6 ?
-
-
3.6.1.27 phosphatidylglycerol phosphate + H2O
-
 Helicobacter pylori phosphatidylglycerol + phosphate
-
 ?
3.6.1.27 phosphatidylglycerol phosphate + H2O
-
 Helicobacter pylori N6 phosphatidylglycerol + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.27 ? x * 25800, SDS-PAGE Helicobacter pylori

Synonyms

EC Number Synonyms Comment Organism
3.6.1.27 C55-PP pyrophosphatase
-
 Helicobacter pylori
3.6.1.27 HP0851
-
 Helicobacter pylori
3.6.1.27 HupA
-
 Helicobacter pylori
3.6.1.27 undecaprenyl pyrophosphate phosphatase
-
 Helicobacter pylori
3.6.1.27 UppP
-
 Helicobacter pylori

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.27 5
-
-
 Helicobacter pylori

General Information

EC Number General Information Comment Organism
3.6.1.27 physiological function the enzyme is essential in vivo for stomach colonization and is also involved in cationic antimicrobial peptide resistance Helicobacter pylori