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Literature summary extracted from

  • Kim, T.D.; Oh, S.; Shin, S.; Janknecht, R.
    Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D (2012), PLoS ONE, 7, e34618 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.66 additional information Homo sapiens the enzyme also demethylates lysine 26 at histone H1.4 ?
-
-
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 Homo sapiens overall reaction [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.66 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.66 HCT-116 cell
-
 Homo sapiens
-
1.14.11.66 HEK-293T cell
-
 Homo sapiens
-
1.14.11.66 U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.66 additional information the enzyme also demethylates lysine 26 at histone H1.4 Homo sapiens ?
-
-
1.14.11.66 additional information no activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine36 Homo sapiens ?
-
-
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 overall reaction Homo sapiens [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.66 JMJD2D
-
 Homo sapiens
1.14.11.66 KDM4D
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.66 malfunction enzyme downregulation inhibits cell proliferation in wild type and even more so in p53-deficient HCT-116 colon cancer cells. Enzyme depletion also induces more strongly apoptosis in p53-deficient compared to wild-type HCT-116 cells Homo sapiens
1.14.11.66 physiological function the enzyme protects HCT-116 cells from apoptosis Homo sapiens