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Literature summary extracted from

  • Ohhara, Y.; Nakamura, A.; Kato, Y.; Yamakawa-Kobayashi, K.
    Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila (2019), PLoS Genet., 15, e1008121 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.4.B10 genes cct1-8 Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.6.4.B10 additional information knockdown of each cct subunit gene in the prothoracic gland (PG). Cell number and C value in the mutant PG are increased compared to wild-type. Usage of an PG-selective RNAi screen to identify MES regulator(s). A statistically significant difference occurs in pH3 expression between control and cct RNAi. cct genes are also required for proper progression of mitotic cell cycle, development is mainly arrested at the L3 stage in cct RNAi animals (phm>cct-RNAi). Ecdysteroidogenic gene expression is significantly reduced in cct RNAi, and 20E administration restores larval-to-pupal transition in 20-30% of animals Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.B10 Drosophila melanogaster P12613 AND Q9W392 AND P48605 AND Q9VK69 AND Q7KKI0 AND Q9VXQ5 AND Q9VHL2 AND Q7K3J0 genes CCT1-8 encoding subunits CCT-alpha, CCT-beta, CCT-gamma, CCT-delta, CCT-epsilon or CCT5 isoform A, CCT-zeta, CCT-eta, and CCT-theta
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3.6.4.B10 Drosophila melanogaster Oregon R P12613 AND Q9W392 AND P48605 AND Q9VK69 AND Q7KKI0 AND Q9VXQ5 AND Q9VHL2 AND Q7K3J0 genes CCT1-8 encoding subunits CCT-alpha, CCT-beta, CCT-gamma, CCT-delta, CCT-epsilon or CCT5 isoform A, CCT-zeta, CCT-eta, and CCT-theta
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.4.B10 larva
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 Drosophila melanogaster
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3.6.4.B10 molting gland prothoracic gland PG, a steroidogenic organ, PG cells undergo approximately four rounds of endocycling Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
3.6.4.B10 CCT
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 Drosophila melanogaster
3.6.4.B10 chaperonin TCP-1 ring complex
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 Drosophila melanogaster
3.6.4.B10 chaperonin TRiC
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 Drosophila melanogaster
3.6.4.B10 TriC
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.6.4.B10 evolution chaperonin TRiC is evolutionarily conserved Drosophila melanogaster
3.6.4.B10 malfunction knockdown of TRiC subunits in the prothoracic gland (PG) causes a prolonged mitotic period, probably due to impaired nuclear translocation of Fizzy-related (Fzr), which also causes loss of ecdysteroidogenic activity. Fzr mediates downregulation of mitotic cyclins Drosophila melanogaster
3.6.4.B10 physiological function chaperonin TCP-1 ring complex (TRiC) supports proper folding of numerous proteins including cell cycle regulators and mediates protein quality control. TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila melanogaster. The evolutionarily conserved chaperonin TRiC is a regulator of the mitotic-to-endocycle switch (MES), which is critical for the prothoracic gland (PG) to upregulate biosynthesis of the steroid hormone ecdysone. TRiC supports proper MES and endocycle progression by regulating Fzr folding. TRiC-mediated protein quality control is proposed to be a conserved mechanism supporting MES and endocycling, as well as subsequent terminal differentiation. TRiC is required for ecdysone biosynthesis in the PG to induce the larval-to-pupal transition. TRiC downregulates CycA by regulating Fzr nuclear translocation to promote MES and endocycling Drosophila melanogaster