Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, W.; Taylor, M.C.; Barrow, R.A.; Croyal, M.; Masle, J.
    Loss of phosphoethanolamine N-methyltransferases abolishes phosphatidylcholine synthesis and is lethal (2019), Plant Physiol., 179, 124-142 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.103 E8A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
2.1.1.103 K13A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
2.1.1.103 R9A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
2.1.1.103 W16A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana
2.1.1.103 Y15A mutation of NMT2 isoform 2, loss of activity Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Arabidopsis thaliana Q944H0 isoform NMT2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.103 flower expression of NMT2 isoform 2 Arabidopsis thaliana
-
2.1.1.103 flower bud expression of NMT2 isoform 2 Arabidopsis thaliana
-
2.1.1.103 leaf rosette or cauline leaf, expression of NMT2 isoform 1 Arabidopsis thaliana
-
2.1.1.103 seedling young seedling, expression of NMT2 isoform 1 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 ethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
 ?
2.1.1.103 additional information the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies Arabidopsis thaliana ?
-
-
2.1.1.103 N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana choline phosphate + S-adenosyl-L-homocysteine
-
 ?
2.1.1.103 N-methylethanolamine phosphate + S-adenosyl-L-methionine
-
 Arabidopsis thaliana N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 NMT2
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.1.1.103 physiological function the isoforms NMT1/NMT3 double knock-out mutant is viable. This is enabled by residual phosphoethanolamine N-methyltransferase activity through isoform NMT2. The triple NMT1/NMT2/NMT3 knock-out mutant cannot synthesize phosphatidylcholine from phosphoethanolamine and is lethal. Through alternative use of its promoter, NMT2 encodes two phosphoethanolamine N-methyltransferase variants, which greatly differ in their ability to perform the initial phosphobase methylation of phosphoethanolamine Arabidopsis thaliana