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Literature summary extracted from

  • Wang, Z.; Wen, L.; Zhu, F.; Wang, Y.; Xie, Q.; Chen, Z.; Li, Y.
    Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma (2017), Oncotarget, 8, 104022-104036 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.299 medicine the combined therapy of enzyme and teniposide VM-26 is a therapeutic strategy for the treatment of human glioma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.299 stearoyl-CoA + a sphingoid base Homo sapiens
-
 an N-(stearoyl)-sphingoid base + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.299 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.299 A-172 cell
-
 Homo sapiens
-
2.3.1.299 brain
-
 Homo sapiens
-
2.3.1.299 central nervous system
-
 Homo sapiens
-
2.3.1.299 glioma cell
-
 Homo sapiens
-
2.3.1.299 U-251MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.299 stearoyl-CoA + a sphingoid base
-
 Homo sapiens an N-(stearoyl)-sphingoid base + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.299 ceramide synthase 1
-
 Homo sapiens
2.3.1.299 CerS1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.299 physiological function enzyme overexpression inhibits cell viability and induces cell death by activating endoplasmic reticulum stress, which induces lethal autophagy and inhibits PI3K/AKT signal pathway in U-251 and A-172 glioma cells. Enzyme overexpression also increases the sensitivity of U-251 and A-172 glioma cells to teniposide (VM-26) Homo sapiens