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Literature summary extracted from

  • Wang, Y.; Maeda, Y.; Liu, Y.S.; Takada, Y.; Ninomiya, A.; Hirata, T.; Fujita, M.; Murakami, Y.; Kinoshita, T.
    Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation (2020), Nat. Commun., 11, 860 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.62 lactosylceramide presence of lactosylceramide is required for B3GALT4 to transfer galalctose to glycosylphosphatidylinositol Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.62 D175A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens
2.4.1.62 D176A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens
2.4.1.62 D177A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.62 Homo sapiens O96024 isoform B3GALT4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.62 HEK-293 cell
-
 Homo sapiens
-
2.4.1.62 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.62 additional information GM1 ganglioside synthase B3GALT4 additionally functions in transferring galactose to the N-acetylgalactosamine side-chain of GPI. B3GALT4 requires lactosylceramide for the efficient GPI side-chain galactosylation Homo sapiens ?
-
-
2.4.1.62 UDP-galactose + ganglioside GA2
-
 Homo sapiens UDP + ganglioside GA1
-
 ?
2.4.1.62 UDP-galactose + N-acetyl-Gal-glycosylphosphatidylinositol
-
 Homo sapiens UDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.62 B3GALT4
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.1.62 physiological function glycosylphosphatidylinositol bearing non-galactosylated GalNAc side-chain increases from 70% to 81% after KO of B3GALT4, however, 18% of the GPI still have one hexose and a GalNAc side-chain Homo sapiens