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Literature summary extracted from

  • Huynh, N.; Ou, Q.; Cox, P.; Lill, R.; King-Jones, K.
    Glycogen branching enzyme controls cellular iron homeostasis via iron regulatory protein 1 and mitoNEET (2019), Nat. Commun., 10, 5463 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.18 Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.18 AGBE
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 Drosophila melanogaster
2.4.1.18 glycogen branching enzyme
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.4.1.18 malfunction enzyme mutations cause porphyria Drosophila melanogaster
2.4.1.18 physiological function the enzyme is a regulator of iron homeostasis. The enzyme interacts physically with the holoform of iron regulatory protein 1A (IRP1A) and Cisd2, an ortholog of vertebrate mitoNEET. This synergistic interaction ensures that holo-IRP1A remains functional Drosophila melanogaster