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Literature summary extracted from

  • Sociali, G.; Liessi, N.; Grozio, A.; Caffa, I.; Parenti, M.; Ravera, S.; Tasso, B.; Benzi, A.; Nencioni, A.; Del Rio, A.; Robina, I.; Millo, E.; Bruzzone, S.
    Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules (2019), Mol. Divers., 24, 655-671 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.B41 G60A the SIRT6 G60A mutant retains an efficient defatty-acylase activity, but has significantly decreased deacetylase activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.B41 (9H-fluoren-9-yl)methyl(6-acetamido-1-(dodecylamino)-1-oxohexan-2-yl)carbamate
-
 Homo sapiens
2.3.1.B41 (9H-fluoren-9-yl)methyl(6-acetamido-1-(dodecylamino)-1-oxohexanyl) carbamate
-
 Homo sapiens
2.3.1.B41 2,4-dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide i.e. compound Q, a SIRT6 inhibitor with quinazolinedione-like structure, which reduces both SIRT6 deacetylase and deacylase activities Homo sapiens
2.3.1.B41 2,6-diamino-N-dodecylhexanamide
-
 Homo sapiens
2.3.1.B41 2,6-diamino-N-octadecylhexanamide
-
 Homo sapiens
2.3.1.B41 2-acetamido-6-amino-N-octadecylhexanamide
-
 Homo sapiens
2.3.1.B41 2-acetamido-6-amino-N-tetradecylhexanamide
-
 Homo sapiens
2.3.1.B41 additional information identification of SIRT6 inhibitors that decrease SIRT6 deacetylase activity and evoke coherent biological effects in cells. These inhibitors include a family of compounds with a quinazolinedione-based structure and a family of compounds with salicylate-based structure, with an IC50 for the SIRT6-catalyzed deacetylase activity in the low micromolar range. Relative enzyme activity in presencee of inhibitors compared to control, overview. No inhibition by (9H-fluoren-9-yl)methyl [(2S)-6-[(tert-butoxycarbonyl)amino]-1-(dodecylamino)-1-oxohexan-2-yl]carbamate and tert-butyl [(5S)-5-acetamido-6-(dodecylamino)-6-oxohexyl]carbamate Homo sapiens
2.3.1.B41 N,N'-(6-(octadecylamino)-6-oxohexane-1,5-diyl)diacetamide
-
 Homo sapiens
2.3.1.B41 N-[(5S)-5-acetamido-6-(dodecylamino)-6-oxohexyl]-N,N-dimethylmethanaminium
-
 Homo sapiens
2.3.1.B41 N2-acetyl-N-dodecyl-L-lysinamide
-
 Homo sapiens
2.3.1.B41 tert-butyl (5-acetamido-6-(octadecylamino)-6-oxohexyl)carbamate
-
 Homo sapiens
2.3.1.B41 tert-butyl (5-amino-6-(dodecylamino)-6-oxohexyl)carbamate
-
 Homo sapiens
2.3.1.B41 tert-butyl (5-amino-6-(octadecylamino)-6-oxohexyl)carbamate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 additional information Homo sapiens sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286 ?
-
-
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 MCF-7 cell
-
 Homo sapiens
-
2.3.1.B41 THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 additional information sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286 Homo sapiens ?
-
-
2.3.1.B41 additional information a myristoyl peptide and a palmitoyl peptide are incubated with sirtuin6. Sirtuin6 exhibits both SIRT6 deacetylase and deacylase activities, cf. EC 2.3.1.286 Homo sapiens ?
-
-
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 SIRT6 deacylase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.B41 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.B41 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.B41 physiological function SIRT6 seems to act as an oncogene, by virtue of its ability to promote DNA repair, cancer cell invasiveness and inflammation Homo sapiens