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Literature summary extracted from

  • Davis, D.L.; Mahawar, U.; Pope, V.S.; Allegood, J.; Sato-Bigbee, C.; Wattenberg, B.W.
    Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination (2020), J. Lipid Res., 61, 505-522 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.50 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine Rattus norvegicus
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.50 Rattus norvegicus D4A2H2 AND Q3B7D2 subunit SPTLC1 and SPTLC2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.50 brain
-
 Rattus norvegicus
-
2.3.1.50 oligodendrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.50 myristoyl-CoA + L-serine
-
 Rattus norvegicus CoA + 2-amino-1-hydroxyhexadecan-3-one + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 stearoyl-CoA + L-serine
-
 Rattus norvegicus CoA + (2S)-2-amino-1-hydroxyicosan-3-one + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.50 heterodimer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.50 serine palmitoyltransferase
-
 Rattus norvegicus
2.3.1.50 SPT
-
 Rattus norvegicus
2.3.1.50 SPTLC1 subunit Rattus norvegicus
2.3.1.50 SPTLC2 subunit Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.3.1.50 Rattus norvegicus the levels of subunits SPTLC1 and 2 progressively increase at both the protein and mRNA levels in oligodendrocytes as the cells differentiate from immature oligodendrocyte progenitors (day 2) into mature myelinating oligodendrocytes (day 16) up