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Literature summary extracted from

  • Kirubakar, G.; Murugaiyan, J.; Schaudinn, C.; Dematheis, F.; Holland, G.; Eravci, M.; Weise, C.; Roesler, U.; Lewin, A.
    Proteome analysis of a M. avium mutant exposes a novel role of the bifunctional protein LysX in the regulation of metabolic activity (2018), J. Infect. Dis., 218, 291-299 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Mycobacterium avium
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Mycobacterium avium 104
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.3 Mycobacterium avium A0QHC4
-
-
2.3.2.3 Mycobacterium avium 104 A0QHC4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Mycobacterium avium tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Mycobacterium avium 104 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.3 LysX
-
 Mycobacterium avium

General Information

EC Number General Information Comment Organism
2.3.2.3 malfunction a Mycobacterium avium lysX mutant strain undergoes a transition in phenotype by switching the carbon metabolism to beta-oxidation of fatty acids, along with accumulation of lipid inclusions. Proteins associated with intracellular survival are upregulated in the lysX mutant, even during extracellular growth, preparing bacteria for the conditions occurring inside host cells. In line with this, the lysX mutant exhibits enhanced intracellular growth in human-blood-derived monocytes Mycobacterium avium
2.3.2.3 metabolism significance of lysX in the metabolism and virulence of the environmental pathogen Mycobacterium avium hominissuis Mycobacterium avium
2.3.2.3 physiological function lysyl-phosphatidylglycerol is one of the components of the mycobacterial membrane that contributes to the resistance to cationic antimicrobial peptides, a host-induced frontline defense against invading pathogens. Its production is catalyzed by LysX, a bifunctional protein with lysyl transferase and lysyl transfer RNA synthetase activity Mycobacterium avium