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Literature summary extracted from

  • Na, I.; DeForte, S.; Stojanovski, B.M.; Ferreira, G.C.; Uversky, V.N.
    Molecular dynamics analysis of the structural and dynamic properties of the functionally enhanced hepta-variant of mouse 5-aminolevulinate synthase (2018), J. Biomol. Struct. Dyn., 36, 152-165 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.37 V501L/Y506R/P510E/R511I/G512N/E513Q/L515K hyperactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Rhodobacter capsulatus
-
 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine Mus musculus
-
 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine Rhodobacter capsulatus ATCC BAA-309
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Mus musculus P08680
-
-
2.3.1.37 Rhodobacter capsulatus P18079
-
-
2.3.1.37 Rhodobacter capsulatus ATCC BAA-309 P18079
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 erythroid cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rhodobacter capsulatus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Rhodobacter capsulatus ATCC BAA-309 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 homodimer
-
 Rhodobacter capsulatus
2.3.1.37 homodimer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 ALAS
-
 Rhodobacter capsulatus
2.3.1.37 ALAS2
-
 Mus musculus
2.3.1.37 hemA
-
 Rhodobacter capsulatus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rhodobacter capsulatus
2.3.1.37 pyridoxal 5'-phosphate
-
 Mus musculus