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Literature summary extracted from

  • Gordon,C.J.; Tchesnokov,E.P.; Woolner, E.; Perry, J.K.; Feng,J.Y.; Porter, D.P.; Götte, M.
    Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency (2020), J. Biol. Chem., 295, 6785-6797 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+3 Human respiratory syncytial virus A
2.7.7.48 remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+3 Severe acute respiratory syndrome coronavirus 2

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.48 0.000001
-
 CTP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.0000089
-
 remdesivir triphosphate pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.00001
-
 remdesivir triphosphate pH 8, 30°C Human respiratory syncytial virus A
2.7.7.48 0.00002
-
 UTP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.00003
-
 ATP pH 8, 30°C Human respiratory syncytial virus A
2.7.7.48 0.00003
-
 ATP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.0064
-
 2'-C-methyl-ATP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.027
-
 dATP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2
2.7.7.48 0.033
-
 ara-ATP pH 8, 30°C Severe acute respiratory syndrome coronavirus 2

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Human respiratory syncytial virus A P28887
-
-
2.7.7.48 Human respiratory syncytial virus A A2 P28887
-
-
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 P0DTD1 containing only nsp5, nsp7, nsp8, and nsp12; 2019-nCoV, SARS-CoV-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 2'-C-methyl-ATP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir
2.7.7.48 ara-ATP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir
2.7.7.48 ATP + RNAn
-
 Human respiratory syncytial virus A diphosphate + RNAn+1
-
 ir
2.7.7.48 ATP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir
2.7.7.48 ATP + RNAn
-
 Human respiratory syncytial virus A A2 diphosphate + RNAn+1
-
 ir
2.7.7.48 CTP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir
2.7.7.48 dATP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir
2.7.7.48 remdesivir triphosphate + RNAn
-
 Human respiratory syncytial virus A diphosphate + RNAn 3'-remdesivir
-
 ir
2.7.7.48 remdesivir triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn 3'-remdesivir
-
 ir
2.7.7.48 remdesivir triphosphate + RNAn
-
 Human respiratory syncytial virus A A2 diphosphate + RNAn 3'-remdesivir
-
 ir
2.7.7.48 UTP + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RNA-directed RNA polymerase L
-
 Human respiratory syncytial virus A
2.7.7.48 RNA-directed RNA polymerase L
-
 Severe acute respiratory syndrome coronavirus 2