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Literature summary extracted from

  • Riedinger, C.; Mendler, M.; Schlotterer, A.; Fleming, T.; Okun, J.; Hammes, H.P.; Herzig, S.; Nawroth, P.P.
    High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans (2018), J. Biol. Chem., 293, 4845-4859 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Caenorhabditis elegans
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 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Caenorhabditis elegans
-
-
-
2.1.2.3 Caenorhabditis elegans Q95QQ4
-
-
3.5.4.10 Caenorhabditis elegans Q95QQ4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 Caenorhabditis elegans tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 5-aminoimidazole-4-carboxamideribonucleotide formyltransferase
-
 Caenorhabditis elegans
2.1.2.3 AICAR-transformylase
-
 Caenorhabditis elegans
2.1.2.3 AICAR-transformylase/IMP cyclohydrolase
-
 Caenorhabditis elegans
2.1.2.3 AICARFT
-
 Caenorhabditis elegans
2.1.2.3 ATIC bifunational enzyme with AICAR-transformylase and IMP cyclohydrolase activities Caenorhabditis elegans
2.1.2.3 atic-1
-
 Caenorhabditis elegans
2.1.2.3 C55F2.1
-
 Caenorhabditis elegans
3.5.4.10 AICAR-transformylase/IMP cyclohydrolase
-
 Caenorhabditis elegans
3.5.4.10 atic-1
-
 Caenorhabditis elegans

Expression

EC Number Organism Comment Expression
2.1.2.3 Caenorhabditis elegans high glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions up
2.1.2.3 Caenorhabditis elegans there is approximately 2.7fold increased enzyme expression at 5 days of high glucose (13 mM) compared with standard conditions (5 mM) up
3.5.4.10 Caenorhabditis elegans high glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions up

General Information

EC Number General Information Comment Organism
2.1.2.3 metabolism the enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. High glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions. Inhibition of atic-1 expression, by RNAi, under high glucose is associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. The enzyme (atic-1) is involved in glucotoxic effects under high glucose conditions, either by blocked atic-1 expression or via induction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and AMP-activated kinase (AMPK) induction Caenorhabditis elegans
2.1.2.3 physiological function enzyme overexpression decreases the median lifespan from 23.6 to 20.6 days compared with control nematodes under standard conditions Caenorhabditis elegans
3.5.4.10 metabolism the enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. High glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions. Inhibition of atic-1 expression, by RNAi, under high glucose is associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. The enzyme (atic-1) is involved in glucotoxic effects under high glucose conditions, either by blocked atic-1 expression or viainduction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and AMP-activated kinase (AMPK) induction Caenorhabditis elegans