Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Braganza, A.; Li, J.; Zeng, X.; Yates, N.; Dey, N.; Andrews, J.; Clark, J.; Zamani, L.; Wang, X.; St Croix, C.; OSullivan, R.; Garcia-Exposito, L.; Brodsky, J.; Sobol, R.
    UBE3B is a calmodulin-regulated, mitochondrion-associated E3 ubiquitin ligase (2017), J. Biol. Chem., 292, 2470-2484 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.B11 Ca2+ when the concentration of calcium is increased, calmodulin is released from UBE3B, resulting in an increase in ubiquitylation activity Homo sapiens
2.3.2.26 Ca2+ when the concentration of calcium is increased, calmodulin is released from UBE3B, resulting in an increase in ubiquitylation activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.B11 C1036A loss of ubiquitylation activity Homo sapiens
2.3.2.26 C1036A loss of ubiquitylation activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.B11 Calmodulin UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine motif. Deletion of the motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in vitro ubiquitylation activity of UBE3B. Changes in calcium levels in vitro disrupt the calmodulin-UBE3B interaction Homo sapiens
2.3.2.26 Calmodulin UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine motif. Deletion of the motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in vitro ubiquitylation activity of UBE3B. Changes in calcium levels in vitro disrupt the calmodulin-UBE3B interaction Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.B11 mitochondrion mitochondrion-associated protein Homo sapiens 5739
-
2.3.2.26 mitochondrion mitochondrion-associated protein Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B11 Homo sapiens Q7Z3V4 isoform UBE3B cf. EC 2.3.2.26
-
2.3.2.26 Homo sapiens Q7Z3V4 isoform UBE3B
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B11 additional information UBE3B shows HECT E3 ubiquitin ligase activity and exhibits time-dependent auto-ubiquitylation activity Homo sapiens ?
-
-
2.3.2.26 additional information UBE3B shows HECT E3 ubiquitin ligase activity and exhibits time-dependent auto-ubiquitylation activity Homo sapiens ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.2.B11 UBE3B
-
 Homo sapiens
2.3.2.26 UBE3B
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.B11 physiological function mutating the catalytic cysteine or deleting the entire HECT domain (amino acids 758-1068) results in loss of UBE3B's ubiquitylation activity. Knockdown of UBE3B in human cells induces changes in mitochondrial morphology and physiology, a decrease in mitochondrial volume, and a severe suppression of cellular proliferation Homo sapiens
2.3.2.26 physiological function mutating the catalytic cysteine or deleting the entire HECT domain (amino acids 758-1068) results in loss of UBE3B's ubiquitylation activity. Knockdown of UBE3B in human cells induces changes in mitochondrial morphology and physiology, a decrease in mitochondrial volume, and a severe suppression of cellular proliferation Homo sapiens