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Literature summary extracted from

  • Araoi, S.; Daitoku, H.; Yokoyama, A.; Kako, K.; Hirota, K.; Fukamizu, A.
    The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans (2018), J. Biochem., 163, 433-440 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.319 additional information arginine methylation levels are increased when elt-2 is silenced, implying that erythroid-like transcription factor (ELT)-2 may have ability to inhibit methyltransferase activity of PRMT-1 Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.319 Caenorhabditis elegans Q9U2X0
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-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.319 PRMT-1
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 Caenorhabditis elegans
2.1.1.319 protein arginine methyltransferase 1
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 Caenorhabditis elegans

Expression

EC Number Organism Comment Expression
2.1.1.319 Caenorhabditis elegans the GATA transcription factor elt-2 is a positive regulator of Pprmt-1:: gfp expression. elt-2 RNAi decreases endogenous PRMT-1 expression at mRNA and protein levels down

General Information

EC Number General Information Comment Organism
2.1.1.319 malfunction the null mutant of Caenorhabditis elegans prmt-1 is viable with no severe phenotype, despite loss of asymmetric arginine dimethylation Caenorhabditis elegans
2.1.1.319 physiological function the enzyme catalyzes asymmetric arginine dimethylation of cellular proteins and thus modulates various biological processes, including gene regulation, RNA metabolism, cell signaling and DNA repair Caenorhabditis elegans