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Literature summary extracted from

  • Markandeyan, D.; Kannaiyan, S.; Suresh, S.; Nimmakayala, R.; Ilamurugan, R.; Santhalingam, K.; Paul, B.
    Virtual screening of phytochemicals for methotrexate like dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase inhibitory property using Molegro virtual docker (2016), Int. J. Pharm. Pharm. Sci., 8, 83-87 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 calotropin
-
 Homo sapiens
2.1.2.3 dicrocin
-
 Homo sapiens
2.1.2.3 mauritine A
-
 Homo sapiens
2.1.2.3 melianone
-
 Homo sapiens
2.1.2.3 methotrexate
-
 Homo sapiens
2.1.2.3 uscharidin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Homo sapiens
-
 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Homo sapiens P31939
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 Homo sapiens tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.1.2.3 AICAR transformylase
-
 Homo sapiens
2.1.2.3 ATIC bifunctional enzyme with 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities Homo sapiens