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Literature summary extracted from

  • Benedek, A.; Poeloeskei, I.; Ozohanics, O.; Vekey, K.; Vertessy, B.G.
    The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase (2018), FEBS Open Bio, 8, 158-167 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 expressed in Escherichia coli BL21 (DE3) Rosetta cells Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 Stl repressor protein from Staphylococcus aureus
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Drosophila melanogaster
-
 dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.23 Ni-NTA column chromatography and Superose 12 gel filtration Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 trimer
-
 Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTPase
-
 Drosophila melanogaster

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.6.1.23 53.3
-
 melting temperature Drosophila melanogaster

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.23 0.00003
-
 at pH 7.5 and 20°C Drosophila melanogaster Stl repressor protein from Staphylococcus aureus