EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.45 | in complex with synthesized inhibitors and with methotrexate | Enterococcus faecalis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 2-(4-hydroxy[1,1'-biphenyl]-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | - |
Enterococcus faecalis | |
2.1.1.45 | 2-[2-(3-methoxyphenoxy)propyl]-4-methyl-1H-isoindole-1,3(2H)-dione | - |
Enterococcus faecalis | |
2.1.1.45 | 4'-[(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl][1,1'-biphenyl]-2-carbonitrile | - |
Enterococcus faecalis | |
2.1.1.45 | 4,5,6,7-tetrachloro-2-[3-(phenylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dione | - |
Enterococcus faecalis | |
2.1.1.45 | methotrexate | - |
Enterococcus faecalis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.0136 | - |
5,10-methylenetetrahydrofolate | pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Enterococcus faecalis | Q834R3 | - |
- |
2.1.1.45 | Enterococcus faecalis ATCC 700802 | Q834R3 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Enterococcus faecalis | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Enterococcus faecalis ATCC 700802 | dihydrofolate + dTMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.45 | ThyA | - |
Enterococcus faecalis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.002 | - |
2-(4-hydroxy[1,1'-biphenyl]-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis | |
2.1.1.45 | 0.013 | - |
2-[2-(3-methoxyphenoxy)propyl]-4-methyl-1H-isoindole-1,3(2H)-dione | pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis | |
2.1.1.45 | 0.024 | - |
4,5,6,7-tetrachloro-2-[3-(phenylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dione | pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis | |
2.1.1.45 | 0.025 | - |
4'-[(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl][1,1'-biphenyl]-2-carbonitrile | pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.013 | - |
pH not specified in the publication, temperature not specified in the publication | Enterococcus faecalis | methotrexate |