Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, Y.; Li, M.; Zhang, H.; Yuan, J.; Zhang, C.; Zhang, K.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.; Ren, L.
    Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents (2016), Eur. J. Med. Chem., 115, 245-256 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 (S)-2-[2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-acetylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-propionylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-2-ylmethyl-acetamide
-
 Homo sapiens
2.1.2.3 2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-3-ylmethyl-acetamide
-
 Homo sapiens
2.1.2.3 2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-4-ylmethyl-acetamide
-
 Homo sapiens
2.1.2.3 3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-2-ylmethyl-propionamide
-
 Homo sapiens
2.1.2.3 3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-3-ylmethyl-propionamide
-
 Homo sapiens
2.1.2.3 3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethylsulfanyl]-N-pyridin-4-ylmethyl-propionamide
-
 Homo sapiens
2.1.2.3 4-8[2-(2-amino-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetamido]methyl]-N-[(pyridin-3-yl)methyl]benzamide
-
 Homo sapiens
2.1.2.3 lometrexol
-
 Homo sapiens
2.1.2.3 methotrexate
-
 Homo sapiens
2.1.2.3 N-(3-[[2-(2-amino-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]sulfanyl]propanoyl)-L-glutamic acid
-
 Homo sapiens
2.1.2.3 N-([[2-(2-amino-4-oxo-4,4a,7,7a-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]sulfanyl]acetyl)-L-glutamic acid
-
 Homo sapiens
2.1.2.3 pemetrexed
-
 Homo sapiens
2.1.2.3 pralatrexate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Homo sapiens
-
 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 A-549 cell
-
 Homo sapiens
-
2.1.2.3 alveolar carcinoma cell
-
 Homo sapiens
-
2.1.2.3 colonic cancer cell
-
 Homo sapiens
-
2.1.2.3 KB cell
-
 Homo sapiens
-
2.1.2.3 nasopharyngeal carcinoma cell
-
 Homo sapiens
-
2.1.2.3 SW-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 Homo sapiens tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
-
 Homo sapiens
2.1.2.3 AICARFTase
-
 Homo sapiens