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Literature summary extracted from

  • Liu, Y.; Wang, X.; Zhan, J.; Hu, J.
    The 138th residue of acetohydroxyacid synthase in Corynebacterium glutamicum is important for the substrate binding specificity (2019), Enzyme Microb. Technol., 129, 109357 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.2.1.6 expressed in Corynebacterium glutamicum wild type strain ATCC14067 and its mutant YTW-104 Corynebacterium glutamicum

Protein Variants

EC Number Protein Variants Comment Organism
2.2.1.6 additional information the 138th (alanine) and 404th (valine) residues in the subunit IlvB play important roles in the substrate preference of the condensation reaction catalyzed by the enzyme Corynebacterium glutamicum
2.2.1.6 additional information the 138th (valine) and 404th (alanine) residues in the subunit IlvB play important roles in the substrate preference of the condensation reaction catalyzed by the enzyme. The 138th valine of subunit IlvB is beneficial for the L-valine biosynthesis Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 2 pyruvate Corynebacterium glutamicum
-
 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate Corynebacterium glutamicum VWB-1
-
 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate Corynebacterium glutamicum IWJ001
-
 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate Corynebacterium glutamicum
-
 acetohydroxybutyrate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate Corynebacterium glutamicum VWB-1
-
 acetohydroxybutyrate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate Corynebacterium glutamicum IWJ001
-
 acetohydroxybutyrate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Corynebacterium glutamicum
-
-
-
2.2.1.6 Corynebacterium glutamicum IWJ001
-
-
-
2.2.1.6 Corynebacterium glutamicum VWB-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 2 pyruvate
-
 Corynebacterium glutamicum 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate
-
 Corynebacterium glutamicum VWB-1 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate
-
 Corynebacterium glutamicum IWJ001 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate
-
 Corynebacterium glutamicum acetohydroxybutyrate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate
-
 Corynebacterium glutamicum VWB-1 acetohydroxybutyrate + CO2
-
 ?
2.2.1.6 pyruvate + 2-oxobutyrate
-
 Corynebacterium glutamicum IWJ001 acetohydroxybutyrate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.2.1.6 acetohydroxyacid synthase
-
 Corynebacterium glutamicum
2.2.1.6 AHAS
-
 Corynebacterium glutamicum
2.2.1.6 ilvB catalytic subunit Corynebacterium glutamicum
2.2.1.6 IlvN regulatory subunit Corynebacterium glutamicum

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.6 thiamine diphosphate
-
 Corynebacterium glutamicum