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Literature summary extracted from

  • Park, W.J.; Brenner, O.; Kogot-Levin, A.; Saada, A.; Merrill, A.H.; Pewzner-Jung, Y.; Futerman, A.H.
    Development of pheochromocytoma in ceramide synthase 2 null mice (2015), Endocr. Relat. Cancer, 22, 623-632 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus the enzyme synthesizes ceramides with very-long (C22-C24) acyl chains a very-long-chain ceramide + CoA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.297 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.297 adrenal gland
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 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base the enzyme synthesizes ceramides with very-long (C22-C24) acyl chains Mus musculus a very-long-chain ceramide + CoA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.297 ceramide synthase 2
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 Mus musculus
2.3.1.297 CerS2
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 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.297 malfunction about 50% of enzyme-null mice develop pheochromocytoma by about 13 months, and the rest shows signs of medullary hyperplasia Mus musculus