Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yin, S.; Jiang, X.; Jiang, H.; Gao, Q.; Wang, F.; Fan, S.; Khan, T.; Jabeen, N.; Khan, M.; Ali, A.; Xu, P.; Pandita, T.; Fan, H.; Zhang, Y.; Shi, Q.
    Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels (2017), Development, 144, 2165-2174 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 Mus musculus
-
 CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Mus musculus Q9D1P2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 granulosa cell
-
 Mus musculus
-
2.3.1.48 oocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16
-
 Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 K (lysine) acetyltransferase 8
-
 Mus musculus
2.3.1.48 KAT8
-
 Mus musculus
2.3.1.48 Mof
-
 Mus musculus
2.3.1.48 MYST1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.48 Mus musculus during oocyte development, there is about 5fold increase between 14 days and full-grown germinal vesicle stage oocytes up

General Information

EC Number General Information Comment Organism
2.3.1.48 malfunction oocyte enzyme deletion results in female infertility, with follicle development failure in the secondary and preantral follicle stages. Enzyme deletion results in abnormal heterochromatin configurations in oocytes. Granulosa cell-specific deletion of the enzyme does not affect follicle development or female fertility Mus musculus
2.3.1.48 physiological function the enzyme has an essential function in oogenesis and is essential for female fertility by regulating antioxidant gene expression. The enzyme directly regulates antioxidant gene expression in oocytes Mus musculus