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Literature summary extracted from
- The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans (2011), Curr. Biol., 21, 1685-1694 .
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.17.24 | cytosol | - |
Mus musculus | 5829 | - |
| 3.4.17.24 | cytosol | - |
Caenorhabditis elegans | 5829 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.24 | Caenorhabditis elegans | O76373 | - |
- |
| 3.4.17.24 | Mus musculus | Q641K1 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.17.24 | CCP1 | - |
Mus musculus |
| 3.4.17.24 | CCPP-1 | - |
Caenorhabditis elegans |
| 3.4.17.24 | cytosolic carboxypeptidase CCP1 | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.17.24 | malfunction | loss of CCP1 in mice causes cerebellar Purkinje cell degeneration. Neuronal degeneration caused by loss of CCP1 in mammals may represent a novel ciliopathy in which cilia are formed but not maintained, depriving the cell of cilia-based signal transduction | Mus musculus |
| 3.4.17.24 | physiological function | CCPP-1 acts as a tubulin deglutamylase that regulates the localization and velocity of kinesin motors, and the structural integrity of microtubules in sensory cilia of a multicellular, living animal | Mus musculus |
| 3.4.17.24 | physiological function | the enzyme regulates the ciliary localization of the kinesin-3 KLP-6 and the polycystin PKD-2 in male-specific sensory neurons in Caenorhabditis elegans. CCPP-1 activity is required for ciliary maintenance but not ciliogenesi | Caenorhabditis elegans |
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Release 2023.1 (January 2023)
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