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Literature summary extracted from

  • Li, S.N.; Cao, Y.F.; Sun, X.Y.; Yang, K.; Liang, Y.J.; Gao, S.S.; Fu, Z.W.; Liu, Y.Z.; Yang, K.; Fang, Z.Z.
    Hydroxy metabolites of polychlorinated biphenyls (OH-PCBs) exhibit inhibitory effects on UDP-glucuronosyltransferases (UGTs) (2018), Chemosphere, 212, 513-522 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 2'-OH-PCB106 2'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition Homo sapiens
2.4.1.17 4'-OH-PCB106 4'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 5 mM used in assay conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A1 isoform Homo sapiens
2.4.1.17 UGT1A7 isoform Homo sapiens
2.4.1.17 UGT2B7 isoform Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.0004
-
 2'-OH-PCB106 isoform UGT1A1, at pH 7.4, temperature not specified in the publication Homo sapiens
2.4.1.17 0.0007
-
 4'-OH-PCB106 isoform UGT1A1, at pH 7.4, temperature not specified in the publication Homo sapiens
2.4.1.17 0.0013
-
 2'-OH-PCB106 isoform UGT1A7, at pH 7.4, temperature not specified in the publication Homo sapiens
2.4.1.17 0.0027
-
 2'-OH-PCB106 isoform UGT2B7, at pH 7.4, temperature not specified in the publication Homo sapiens
2.4.1.17 0.0048
-
 4'-OH-PCB106 isoform UGT2B7, at pH 7.4, temperature not specified in the publication Homo sapiens
2.4.1.17 0.0068
-
 4'-OH-PCB106 isoform UGT1A7, at pH 7.4, temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.17 0.00156
-
 isoform UGT1A1, at pH 7.4, temperature not specified in the publication Homo sapiens 4'-OH-PCB106
2.4.1.17 0.0016
-
 isoform UGT1A1, at pH 7.4, temperature not specified in the publication Homo sapiens 2'-OH-PCB106
2.4.1.17 0.00276
-
 isoform UGT2B7, at pH 7.4, temperature not specified in the publication Homo sapiens 2'-OH-PCB106
2.4.1.17 0.00551
-
 isoform UGT2B7, at pH 7.4, temperature not specified in the publication Homo sapiens 4'-OH-PCB106
2.4.1.17 0.01502
-
 isoform UGT1A7, at pH 7.4, temperature not specified in the publication Homo sapiens 2'-OH-PCB106
2.4.1.17 0.03047
-
 isoform UGT1A7, at pH 7.4, temperature not specified in the publication Homo sapiens 4'-OH-PCB106