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Literature summary extracted from

  • Yin, Y.; Sasaki, S.; Taniguchi, Y.
    Inhibitory effect of 8-halogenated 7-deaza-2-deoxyguanosine triphosphates on human 8-oxo-2'-deoxyguanosine triphosphatase, hMTH1, activities (2016), ChemBioChem, 17, 566-569 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.55 (S)-crizotinib
-
 Homo sapiens
3.6.1.55 2-hydroxy-dADP inhibitory at low-micromolar concentrations Homo sapiens
3.6.1.55 2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol i.e. SCH51344 Homo sapiens
3.6.1.55 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine i.e. TH287, strongest inhibitor Homo sapiens
3.6.1.55 7-deaza-dGTP
-
 Homo sapiens
3.6.1.55 7-iodo-7-deaza-dGTP
-
 Homo sapiens
3.6.1.55 8-bromo-7-deaza-dGTP
-
 Homo sapiens
3.6.1.55 8-bromo-dGTP
-
 Homo sapiens
3.6.1.55 8-chloro-7-deaza-dGTP
-
 Homo sapiens
3.6.1.55 8-iodo-7-deaza-2'-deoxyguanosine
-
 Homo sapiens
3.6.1.55 8-iodo-7-deaza-dGTP
-
 Homo sapiens
3.6.1.55 8-oxo-dGDP inhibitory at low-micromolar concentrations Homo sapiens
3.6.1.55 dGTP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.55 0.014
-
 8-oxo-dGTP at pH 7.5 and 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.55 Mg2+ 4 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.55 8-oxo-dGTP + H2O Homo sapiens
-
 8-oxo-dGMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.55 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.55 8-oxo-dGTP + H2O
-
 Homo sapiens 8-oxo-dGMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.55 8-oxo-2'-deoxyguanosine triphosphatase
-
 Homo sapiens
3.6.1.55 8-oxo-dG triphosphatase
-
 Homo sapiens
3.6.1.55 MTH1
-
 Homo sapiens
3.6.1.55 NUDT1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.55 18.9
-
 8-oxo-dGTP at pH 7.5 and 37°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.55 0.0000028
-
 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine at pH 7.5 and 37°C Homo sapiens
3.6.1.55 0.0000617
-
 8-bromo-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
3.6.1.55 0.000117
-
 8-chloro-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
3.6.1.55 0.000203
-
 (S)-crizotinib at pH 7.5 and 37°C Homo sapiens
3.6.1.55 0.000213
-
 7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
3.6.1.55 0.00065
-
 7-iodo-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.55 0.00001
-
 at pH 7.5 and 37°C Homo sapiens 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
3.6.1.55 0.00042
-
 at pH 7.5 and 37°C Homo sapiens 8-iodo-7-deaza-dGTP
3.6.1.55 0.0005
-
 at pH 7.5 and 37°C Homo sapiens 8-bromo-7-deaza-dGTP
3.6.1.55 0.00086
-
 at pH 7.5 and 37°C Homo sapiens 8-chloro-7-deaza-dGTP
3.6.1.55 0.001
-
 at pH 7.5 and 37°C Homo sapiens (S)-crizotinib
3.6.1.55 0.00157
-
 at pH 7.5 and 37°C Homo sapiens 7-deaza-dGTP
3.6.1.55 0.00223
-
 at pH 7.5 and 37°C Homo sapiens 2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
3.6.1.55 0.00262
-
 at pH 7.5 and 37°C Homo sapiens 7-iodo-7-deaza-dGTP
3.6.1.55 0.01675
-
 at pH 7.5 and 37°C Homo sapiens 8-bromo-dGTP
3.6.1.55 0.0448
-
 at pH 7.5 and 37°C Homo sapiens 8-iodo-7-deaza-2'-deoxyguanosine
3.6.1.55 1.998
-
 at pH 7.5 and 37°C Homo sapiens dGTP