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Literature summary extracted from
- NTPDase activities possible roles on Leishmania spp. infectivity and virulence (2018), Cell Biol. Int., 42, 670-682 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.6.1.5 | gene LMJF_15_0030, sequence comparisons | Leishmania major |
| 3.6.1.15 | sequence comparisons | Leishmania infantum |
| 3.6.1.15 | sequence comparisons | Leishmania donovani |
| 3.6.1.15 | sequence comparisons | Leishmania mexicana |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.6.1.5 | intracellular | - |
Leishmania major | 5622 | - |
| 3.6.1.15 | plasma membrane | - |
Leishmania infantum | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.5 | GDP + H2O | Leishmania major | - |
GMP + phosphate | - |
ir |  |
| 3.6.1.5 | GTP + H2O | Leishmania major | - |
GDP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | Leishmania infantum | - |
AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | Leishmania donovani | - |
AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | Leishmania mexicana | - |
AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | Leishmania mexicana MHOM/GT/2001/U1103 | - |
AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | Leishmania donovani BPK282A1 | - |
AMP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | Leishmania infantum | - |
ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | Leishmania donovani | - |
ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | Leishmania mexicana | - |
ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | Leishmania mexicana MHOM/GT/2001/U1103 | - |
ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | Leishmania donovani BPK282A1 | - |
ADP + phosphate | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.5 | Leishmania major | Q4QFI1 | - |
- |
| 3.6.1.15 | Leishmania donovani | E9BA63 | - |
- |
| 3.6.1.15 | Leishmania donovani BPK282A1 | E9BA63 | - |
- |
| 3.6.1.15 | Leishmania infantum | - |
- |
- |
| 3.6.1.15 | Leishmania mexicana | E9AN23 | - |
- |
| 3.6.1.15 | Leishmania mexicana | E9AQ00 | - |
- |
| 3.6.1.15 | Leishmania mexicana MHOM/GT/2001/U1103 | E9AN23 | - |
- |
| 3.6.1.15 | Leishmania mexicana MHOM/GT/2001/U1103 | E9AQ00 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.5 | GDP + H2O | - |
Leishmania major | GMP + phosphate | - |
ir | |
| 3.6.1.5 | GTP + H2O | - |
Leishmania major | GDP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | - |
Leishmania infantum | AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | - |
Leishmania donovani | AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | - |
Leishmania mexicana | AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | - |
Leishmania mexicana MHOM/GT/2001/U1103 | AMP + phosphate | - |
ir | |
| 3.6.1.15 | ADP + H2O | - |
Leishmania donovani BPK282A1 | AMP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | - |
Leishmania infantum | ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | - |
Leishmania donovani | ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | - |
Leishmania mexicana | ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | - |
Leishmania mexicana MHOM/GT/2001/U1103 | ADP + phosphate | - |
ir | |
| 3.6.1.15 | ATP + H2O | - |
Leishmania donovani BPK282A1 | ADP + phosphate | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.5 | ATP diphosphohydrolase | - |
Leishmania major |
| 3.6.1.5 | LmjF15.0030 | locus name | Leishmania major |
| 3.6.1.5 | LmNTPDase 1 | - |
Leishmania major |
| 3.6.1.5 | NTPD1 | - |
Leishmania major |
| 3.6.1.5 | nucleoside triphosphate diphosphohydrolase | - |
Leishmania major |
| 3.6.1.15 | LDBPK_100150 | - |
Leishmania donovani |
| 3.6.1.15 | LdNTPDase2 | - |
Leishmania donovani |
| 3.6.1.15 | LINF_150005200 | - |
Leishmania infantum |
| 3.6.1.15 | LiNTPDase1 | - |
Leishmania infantum |
| 3.6.1.15 | LMXM_10_0170 | - |
Leishmania mexicana |
| 3.6.1.15 | LMXM_15_0030 | - |
Leishmania mexicana |
| 3.6.1.15 | LmxNTPDase1 | - |
Leishmania mexicana |
| 3.6.1.15 | LmxNTPDase2 | - |
Leishmania mexicana |
| 3.6.1.15 | NTPDase | - |
Leishmania infantum |
| 3.6.1.15 | NTPDase | - |
Leishmania donovani |
| 3.6.1.15 | NTPDase | - |
Leishmania mexicana |
| 3.6.1.15 | NTPDase1 | - |
Leishmania infantum |
| 3.6.1.15 | NTPDase1 | - |
Leishmania mexicana |
| 3.6.1.15 | NTPDase2 | - |
Leishmania donovani |
| 3.6.1.15 | NTPDase2 | - |
Leishmania mexicana |
| 3.6.1.15 | nucleoside triphosphate diphosphohydrolase | - |
Leishmania infantum |
| 3.6.1.15 | nucleoside triphosphate diphosphohydrolase | - |
Leishmania donovani |
| 3.6.1.15 | nucleoside triphosphate diphosphohydrolase | - |
Leishmania mexicana |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.6.1.5 | evolution | nucleoside triphosphate diphosphohydrolases (NTPDases) belong to the GDA1/CD39 protein superfamily, E-NTPDase family. Existence of several isoforms with different specificities with respect to divalent cations (magnesium, calcium, manganese, and zinc) and substrates | Leishmania major |
| 3.6.1.15 | evolution | nucleoside triphosphate diphosphohydrolases (NTPDases) belong to the GDA1/CD39 protein superfamily, E-NTPDase family. Existence of several isoforms with different specificities with respect to divalent cations (magnesium, calcium, manganese, and zinc) and substrates. Sequence comparisons of regions of the putative Leishmania NTPDases with human CD39 (NTPDase 1) | Leishmania donovani |
| 3.6.1.15 | evolution | nucleoside triphosphate diphosphohydrolases (NTPDases) belong to the GDA1/CD39 protein superfamily, E-NTPDase family. Existence of several isoforms with different specificities with respect to divalent cations (magnesium, calcium, manganese, and zinc) and substrates. Sequence comparisons of regions of the putative Leishmania NTPDases with human CD39 (NTPDase 1) | Leishmania mexicana |
| 3.6.1.15 | evolution | nucleoside triphosphate diphosphohydrolases (NTPDases) belong to the GDA1/CD39 protein superfamily, E-NTPDase family. Existence of several isoforms with different specificities with respect to divalent cations (magnesium, calcium, manganese, and zinc) and substrates. The sequential hydrolysis of extracellular ATP to adenosine indicates that not only E-NTPDase but also 5'-nucleotidases are present in the plasma membrane. Sequence comparisons of regions of the putative Leishmania NTPDases with human CD39 (NTPDase 1) | Leishmania infantum |
| 3.6.1.15 | physiological function | in parasites of the genus Leishmania, the causative agents of leishmaniasis, two NTPDase isoforms, termed NTPDase-1 and NTPDase-2 have been described. Independently of their cellular localization, whether cell-surface localized, secreted or targeted to other organelles, in some Leishmania species these NTPDases are involved in parasite growth, infectivity, and virulence. Nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of a variety of nucleoside tri- and diphosphates to the monophosphate forms and have been implicated in adenosine acquisition, the regulation of blood clotting, inflammatory responses, immune reactions, and microbial virulence | Leishmania infantum |
| 3.6.1.15 | physiological function | in parasites of the genus Leishmania, the causative agents of leishmaniasis, two NTPDase isoforms, termed NTPDase-1 and NTPDase-2 have been described. Independently of their cellular localization, whether cell-surface localized, secreted or targeted to other organelles, in some Leishmania species these NTPDases are involved in parasite growth, infectivity, and virulence. Nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of a variety of nucleoside tri- and diphosphates to the monophosphate forms and have been implicated in adenosine acquisition, the regulation of blood clotting, inflammatory responses, immune reactions, and microbial virulence | Leishmania donovani |
| 3.6.1.15 | physiological function | in parasites of the genus Leishmania, the causative agents of leishmaniasis, two NTPDase isoforms, termed NTPDase-1 and NTPDase-2 have been described. Independently of their cellular localization, whether cell-surface localized, secreted or targeted to other organelles, in some Leishmania species these NTPDases are involved in parasite growth, infectivity, and virulence. Nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of a variety of nucleoside tri- and diphosphates to the monophosphate forms and have been implicated in adenosine acquisition, the regulation of blood clotting, inflammatory responses, immune reactions, and microbial virulence | Leishmania mexicana |
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Release 2023.1 (January 2023)
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