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Literature summary extracted from

  • Shin, K.S.; Lee, S.K.
    Introduction of an acetyl-CoA carboxylation bypass into Escherichia coli for enhanced free fatty acid production (2017), Biores. Technol., 245, 1627-1633 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.3.1 expressed in Escherichia coli strain SBF15 Propionibacterium freudenreichii subsp. shermanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.1 (S)-methylmalonyl-CoA + pyruvate Propionibacterium freudenreichii subsp. shermanii
-
 propanoyl-CoA + oxaloacetate
-
 r
2.1.3.1 (S)-methylmalonyl-CoA + pyruvate Propionibacterium freudenreichii subsp. shermanii KCTC5753
-
 propanoyl-CoA + oxaloacetate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.1 Propionibacterium freudenreichii subsp. shermanii
-
-
-
2.1.3.1 Propionibacterium freudenreichii subsp. shermanii KCTC5753
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.1 (S)-methylmalonyl-CoA + pyruvate
-
 Propionibacterium freudenreichii subsp. shermanii propanoyl-CoA + oxaloacetate
-
 r
2.1.3.1 (S)-methylmalonyl-CoA + pyruvate
-
 Propionibacterium freudenreichii subsp. shermanii KCTC5753 propanoyl-CoA + oxaloacetate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.3.1 methylmalonyl-CoA carboxyltransferase
-
 Propionibacterium freudenreichii subsp. shermanii
2.1.3.1 MMC
-
 Propionibacterium freudenreichii subsp. shermanii

General Information

EC Number General Information Comment Organism
2.1.3.1 metabolism the enzyme provides an alternative pathway for malonyl-CoA synthesis and increases fatty acid production. The enzyme efficiently directs tricarboxylic acid cycle intermediates towards fatty acid synthesis during the acetyl-CoA carboxylation bypass Propionibacterium freudenreichii subsp. shermanii