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Literature summary extracted from

  • Davis, B.W.; Aumiller, W.M.; Hashemian, N.; An, S.; Armaou, A.; Keating, C.D.
    Colocalization and sequential enzyme activity in aqueous biphasic systems experiments and modeling (2015), Biophys. J., 109, 2182-2194 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.3 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.01
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 66 mM Tris, pH 7.4, 50 mM KCl, temperature not specified in the publication Homo sapiens
2.1.2.3 0.016
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide dextran-rich phase, at pH 7.4, temperature not specified in the publication Homo sapiens
2.1.2.3 0.0168
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 33 mM Tris, pH 7.4, 25 mM KCl, temperature not specified in the publication Homo sapiens
2.1.2.3 0.019
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide PEG-rich phase, at pH 7.4, temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Homo sapiens
-
 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 Homo sapiens tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase
-
 Homo sapiens
2.1.2.3 AICAR transformylase
-
 Homo sapiens
2.1.2.3 AICARTfase
-
 Homo sapiens
2.1.2.3 ATIC bifunctional enzyme showing 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.2.3 2.9
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 66 mM Tris, pH 7.4, 50 mM KCl, temperature not specified in the publication Homo sapiens
2.1.2.3 6.5
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide PEG-rich phase, at pH 7.4, temperature not specified in the publication Homo sapiens
2.1.2.3 7
-
 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide dextran-rich phase, at pH 7.4, temperature not specified in the publication Homo sapiens