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Literature summary extracted from

  • Li, Y.; Xue, M.; Sheng, X.; Yu, H.; Zeng, J.; Thon, V.; Chen, Y.; Muthana, M.; Wang, P.; Chen, X.
    Donor substrate promiscuity of bacterial beta1-3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of beta1-4-galactosyltransferases (2016), Bioorg. Med. Chem., 24, 1696-1705 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.38 expressed in Escherichia coli BL21(DE3) cells Bos taurus
2.4.1.38 expressed in Escherichia coli BL21(DE3) cells Neisseria meningitidis
2.4.1.38 expressed in Escherichia coli BL21(DE3) cells Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Bos taurus
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Neisseria meningitidis
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Helicobacter pylori
-
 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.38 Bos taurus
-
-
-
2.4.1.38 Helicobacter pylori
-
-
-
2.4.1.38 Neisseria meningitidis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.38 Ni-NTA column chromatography Bos taurus
2.4.1.38 Ni-NTA column chromatography Neisseria meningitidis
2.4.1.38 Ni-NTA column chromatography Helicobacter pylori

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.38 additional information no activity with Glcbeta(1->3)Lacbeta-MU, GlcNAc6Sbeta(1->3)Lacbeta-MU, GlcNAc6N3beta(1->3)Lacbeta-MU, GlcNAc6NH2beta(1->3)Lacbeta-MU, GlcNAcPhPhbeta(1->3)Lacbeta-MU, GlcNGcbeta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Bos taurus ?
-
-
2.4.1.38 additional information no activity with Glcbeta(1->3)Lacbeta-MU, GlcNAcPhPhbeta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Helicobacter pylori ?
-
-
2.4.1.38 additional information no activity with GlcNAc6Sbeta(1->3)Lacbeta-MU, GlcNAc6NH2beta(1->3)Lacbeta-MU, GlcNH2beta(1->3)Lacbeta-MU, GalNAcbeta(1->3)Lacbeta-MU or Galbeta(1->)3Lacbeta-MU as acceptor Neisseria meningitidis ?
-
-
2.4.1.38 UDP-alpha-D-galactose +
-
 Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-Glc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 95-100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 90-95% activity Bos taurus ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc-N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 35-40% activity Bos taurus ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6N3(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 5-10% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6NH2(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 20% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAc6OSO3-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 20-25% activity Bos taurus ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 50% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNAcPhPh(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNGc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 75-80% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNGc(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 90-95% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 100% activity Helicobacter pylori ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 95-100% activity Neisseria meningitidis ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + 4-methylumbelliferyl beta-D-GlcNTFA-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc 60-65% activity Bos taurus ?
-
 ?
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Bos taurus UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Neisseria meningitidis UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Helicobacter pylori UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.38 beta1-4-galactosyltransferase
-
 Bos taurus
2.4.1.38 beta1-4-galactosyltransferase
-
 Neisseria meningitidis
2.4.1.38 beta1-4-galactosyltransferase
-
 Helicobacter pylori
2.4.1.38 beta4GalT
-
 Bos taurus
2.4.1.38 beta4GalT
-
 Neisseria meningitidis
2.4.1.38 beta4GalT
-
 Helicobacter pylori
2.4.1.38 LgtB
-
 Neisseria meningitidis