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Literature summary extracted from

  • Sharma, S.; Ahmed, M.; Akhter, Y.
    The revelation of selective sphingolipid pathway inhibition mechanism on fumonisin toxin binding to ceramide synthases in susceptible organisms and survival mechanism in resistant species (2018), Biochimie, 149, 41-50 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.24 molecular modeling of structure, binding of inhibitor fumonisin B1 and comparison with structure of Saccharomyces cerevisiae enzyme Trichoderma guizhouense
2.3.1.24 molecular modeling of structure, binding of inhibitor fumonisin B1 and comparison with structure of Trichoderma guizhouense enzyme Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 fumonisin B1 competitive, a refolding of activation loop during fumonisin binding results in catalytic inhibition Saccharomyces cerevisiae
2.3.1.24 fumonisin B1 formation of a stable protein-substrate-inhibitor complex. The three molecules bind at different positions within the conserved active site and during a molecular dynamics simulation run no evident change regarding the substitution of sites with substrates and the inhibitor could be observed Trichoderma guizhouense

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Saccharomyces cerevisiae P38703
-
-
2.3.1.24 Trichoderma guizhouense A0A1T3CVR0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 acyl-CoA + phytosphingosine
-
 Saccharomyces cerevisiae CoA + N-acylphytosphingosine
-
 ?
2.3.1.24 acyl-CoA + phytosphingosine
-
 Trichoderma guizhouense CoA + N-acylphytosphingosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 LAG1
-
 Trichoderma guizhouense
2.3.1.24 LAG1
-
 Saccharomyces cerevisiae