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Literature summary extracted from

  • Chatterjee, T.; Das, G.; Chatterjee, B.K.; Dhar, J.; Ghosh, S.; Chakrabarti, P.
    The role of isoaspartate in fibrillation and its prevention by protein-L-isoaspartyl methyltransferase (2019), Biochim. Biophys. Acta, 1864, 129500 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.77 stiripentol stabilizes the enzyme, binds close to the cofactor binding site, and increases the enzymatic activity Rattus norvegicus
2.1.1.77 Valproic acid stabilizes the enzyme, binds close to the cofactor binding site, and increases the enzymatic activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Rattus norvegicus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.77 PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + Val-Tyr-Pro-(isoAsp)-His-Ala
-
 Rattus norvegicus S-adenosyl-L-homocysteine + Val-Tyr-Pro-(isoAsp-alpha-methyl ester)-His-Ala
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 PIMT
-
 Rattus norvegicus
2.1.1.77 protein-L-isoaspartyl methyltransferase
-
 Rattus norvegicus