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Literature summary extracted from

  • Meng, Q.; Liang, H.; Gao, H.
    Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance (2018), Biochim. Biophys. Acta, 1863, 1153-1163 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.180 cerulenin
-
 Shewanella oneidensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] Shewanella oneidensis
-
 an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] Shewanella oneidensis ATCC 700550
-
 an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Shewanella oneidensis
-
-
-
2.3.1.180 Shewanella oneidensis ATCC 700550
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein]
-
 Shewanella oneidensis an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein]
-
 Shewanella oneidensis ATCC 700550 an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-ACP synthase
-
 Shewanella oneidensis
2.3.1.180 FabH
-
 Shewanella oneidensis
2.3.1.180 FabH1 isoform Shewanella oneidensis
2.3.1.180 FabH2 isoform Shewanella oneidensis
2.3.1.180 FabH3 isoform Shewanella oneidensis
2.3.1.180 KASIII
-
 Shewanella oneidensis

Expression

EC Number Organism Comment Expression
2.3.1.180 Shewanella oneidensis isoform FabH2 is cold-inducible and shows about 2fold increase of expression after cold-shock (8°C) treatment up

General Information

EC Number General Information Comment Organism
2.3.1.180 metabolism isoforms FabH1 and FabH2 have major roles in straight-chain fatty acid and branched-chain fatty acid biosynthesis, respectively Shewanella oneidensis