EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.13 | isoleucine | inhibited by leucine and isoleucine. Leucine is a more effective inhibitor | Thermus thermophilus | |
2.3.3.13 | leucine | inhibited by leucine and isoleucine. Leucine is a more effective inhibitor | Thermus thermophilus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.13 | 0.023 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus | |
2.3.3.13 | 0.054 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | Thermus thermophilus | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | (2S)-2-isopropylmalate + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.3.13 | Thermus thermophilus | Q72JC9 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.13 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | - |
Thermus thermophilus | (2S)-2-isopropylmalate + CoA | - |
? | |
2.3.3.13 | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | Thermus thermophilus | (2S)-2-isopropylmalate + CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.3.13 | IPMS | - |
Thermus thermophilus |
2.3.3.13 | TT_C0849 | - |
Thermus thermophilus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.13 | 1.2 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus | |
2.3.3.13 | 1.7 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.3.13 | metabolism | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | Thermus thermophilus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.13 | 22 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus | |
2.3.3.13 | 73 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus |