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Literature summary extracted from

  • Gao, T.; Zhao, X.; Liu, C.; Shao, B.; Zhang, X.; Li, K.; Cai, J.; Wang, S.; Huang, X.
    Somatic angiotensin I-converting enzyme regulates self-renewal of mouse spermatogonial stem cells through the mitogen-activated protein kinase signaling pathway (2018), Stem Cells Dev., 27, 1021-1032 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.15.1 additional information lentivirus-mediated shRNA knockdown of somatic ACE, sAce Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril ACE competitive inhibitor, inhibits somatic ACE activity. Captopril significantly lowers the percentage of cells in the S phase and significantly increases the percentage of cells in the G0/G1 phase compared with the negative control, whereas the percentage of cells in each cell cycle phase nearly recovers following captopril withdrawal Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.15.1 membrane associated, sACE Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zn2+ ACE is a zinc dipeptidyl carboxypeptidase Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Mus musculus
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Mus musculus P09470
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 spermatogonial stem cell spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse cultured spermatogonial stem cells (SSCs) Mus musculus
-
3.4.15.1 testis spermatogonial, somatic ACE (sACE), but not testicular ACE (tACE), is expressed in mouse testis before postpartum day 7 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Mus musculus angiotensin II + L-His-L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Mus musculus
3.4.15.1 angiotensin I-converting enzyme
-
 Mus musculus
3.4.15.1 sACE
-
 Mus musculus
3.4.15.1 TACE
-
 Mus musculus
3.4.15.1 zinc dipeptidyl carboxypeptidase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.15.1 malfunction sAce knockdown through shRNAs impairs proliferation of mouse spermatogonial stem cells in vitro and leads to smaller colony size Mus musculus
3.4.15.1 metabolism angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system Mus musculus
3.4.15.1 physiological function ACE is a well-characterized zinc peptidase that removes C-terminal dipeptides from substrates such as angiotensin I and bradykinin leading to an increase in blood pressure. Angiotensin I-converting enzyme (ACE) plays a critical role in the regulation of the renin-angiotensin system. Somatic ACE, sACE, plays an important role in spermatogonial stem cell (SSC) self-renewal through the regulation of MAPK-dependent cell proliferation. sACE is required for the self-renewal of SSCs through the MAPK signaling pathway Mus musculus