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Literature summary extracted from

  • Pinter, N.; Hach, C.A.; Hampel, M.; Rekhter, D.; Zienkiewicz, K.; Feussner, I.; Poehlein, A.; Daniel, R.; Finkernagel, F.; Heimel, K.
    Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis (2019), PLoS Pathog., 15, e1007734 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.B24 gene spp1 or UMAG_02729, phylogenetic tree, quantitative RT-PCR enzyme expression analysis Ustilago maydis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.23.B24 additional information generation of DELTAspp1 strains. DELTAspp1 strains do not show increased expression of fungal UPR marker genes in planta. DELTAspp1 strains are not impaired in H2O2 resistance Ustilago maydis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.B24 endoplasmic reticulum membrane Spp1 displays the characteristic SPP domain structure with 9 predicted trans membrane (TM) domains Ustilago maydis 5789
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Organism

EC Number Organism UniProt Comment Textmining
3.4.23.B24 Ustilago maydis A0A0D1E4M7
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3.4.23.B24 Ustilago maydis 521 A0A0D1E4M7
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3.4.23.B24 Ustilago maydis FGSC 9021 A0A0D1E4M7
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.B24 additional information plant infection studies using the Zea mays cultivar Early Golden Bantam Ustilago maydis
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Synonyms

EC Number Synonyms Comment Organism
3.4.23.B24 SPP1
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 Ustilago maydis
3.4.23.B24 UMAG_02729
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 Ustilago maydis

Expression

EC Number Organism Comment Expression
3.4.23.B24 Ustilago maydis spp1 belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant up

General Information

EC Number General Information Comment Organism
3.4.23.B24 malfunction loss of virulence is connected to the catalytic activity of Spp1 to interfere with plant defense responses. Endoplasmic reticulum stress resistance of UPR core gene deletion mutants. DELTAspp1 strains do not show increased expression of fungal UPR marker genes in planta. DELTAspp1 strains are not impaired in H2O2 resistance Ustilago maydis
3.4.23.B24 metabolism gene spp1, encoding the signal peptide peptidase, belongs to the unfolded protein response (UPR) core genes identified under stringent filtering criteria and expression of spp1 is strongly induced in planta. Activation of the UPR is connected to the control of fungal proliferation through direct protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. This interaction leads to functional modification of Cib1 and modulation of UPR gene expression to adapt the UPR for long-term activity in the plant. The virulence specific function of Spp1 does not involve pathways previously known to be associated with Spp1-like proteins or plant defense suppression Ustilago maydis
3.4.23.B24 physiological function signal peptide peptidase activity connects the unfolded protein response (UPR) to plant defense suppression by Ustilago maydis. The corn smut fungus Ustilago maydis requires the unfolded protein response to maintain homeostasis of the endoplasmic reticulum during the biotrophic interaction with its host plant Zea mays. The signal peptide peptidase Spp1 is a key factor that is required for establishing a compatible biotrophic interaction between Ustilago maydis and its host plant maize. Spp1 is dispensable for endoplasmic reticulum stress resistance and vegetative growth but its catalytic activity is required to interfere with the plant defense, revealing a virulence specific function for signal peptide peptidases in a biotrophic fungal/plant interaction. The UPR-regulated signal peptide peptidase Spp1 is dispensable for vegetative growth or filament formation, but is of crucial importance to establish a compatible biotrophic interaction and cause disease Ustilago maydis